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Abstract: We have developed the zebrafish as a model for tuberculosis, exploiting its genetic tractability and optical transparency to study host-mycobacterium interactions in real-time. Starting with a forward genetic screen in the zebrafish, we have identified an enzyme in the eicosanoid pathway that mediates susceptibility to TB in the zebrafish and in humans. Dissection of the pathway in the zebrafish has revealed a pathogenic macrophage cell death pathway that operates through a mitochondrial - ER - lysosomal circuit. The identification of the pathway has led to multiple host-targeting drugs that may be useful in the treatment of TB as well as other inflammatory conditions where this newly-discovered pathway may be operant.

Have you ever wondered what is sleep? How do we know when to sleep? How much sleep do we need? In this talk Michelle will explore these questions and more. You'll hear about the implications of changes in society upon sleep patterns, the concept of sleep loss and sleep debt, and the potential implications of sleep disturbances (both quality and quantity) for both our society and also for individuals. For example did you know sleep loss may be a possible causative factor for disease development? Join us for a fascinating talk and some all important tips for a good night's sleep!

We all love stories. When we go to a therapist we want them to understand where we are and listen with empathy to our own story. But how do therapists learn that? Is it possible to measure ‘empathy’? Andrew uses published illness narratives, in books and films, to expose physiotherapy students to alternative views of illness and trauma. Now he is trying to investigate whether you can measure the effectiveness of such an approach.