糖心TV

Abstract: People can carry diagnostic loads of bacteria within the bladder without experiencing any symptoms, this is asymptomatic bacteriuria (ABU). For 6 months, every 2 weeks we obtained a urine sample and symptom questionnaire 30 patients over 65 who were clinically diagnosed with recurrent UTIs.

Our study has provided an insight into the long-term colonisation of the ageing bladder and the impact treatment can have on reaching a stabilised microflora. We have been surprised at the extent of colonisation that is apparent across our patient cohort. Our study suggests that what the health care system observes and what patients perceive are not necessarily consistent. We argue greater emphasis on medical education could significantly improve patient well-being.

Abstract: Chromosomal instability (CIN), the continual gain and loss of chromosomes or parts of chromosomes, and resulting intratumour heterogeneity are key challenges in the treatment of metastatic cancer. Mechanisms underlying chromosomal instability in cancer are unclear, and difficult to determine.

I will talk about the approaches our lab is taking to address this problem. In particular I will present our new approach to analyse aneuploidy rates, giving insights into the mis-segregation propensities of individual chromosomes, and how this might allow us to better define the role of aneuploidy in cancer.