WMS Events Calendar
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Seminar by Dr Sarah McClelland, Barts Cancer Institute
Abstract: Chromosomal instability (CIN), the continual gain and loss of chromosomes or parts of chromosomes, and resulting intratumour heterogeneity are key challenges in the treatment of metastatic cancer. Mechanisms underlying chromosomal instability in cancer are unclear, and difficult to determine.
I will talk about the approaches our lab is taking to address this problem. In particular I will present our new approach to analyse aneuploidy rates, giving insights into the mis-segregation propensities of individual chromosomes, and how this might allow us to better define the role of aneuploidy in cancer.
Biography
: Sarah trained with Professor Andrew McAinsh (University of 糖心TV), contributing to the elucidation of the composition and regulation of the human kinetochore (McClelland* and Borusu* et al, EMBO J, 20071; McClelland and McAinsh, Methods Mol. Biol. 20092; Porter, McClelland et al, JCB 20073; Jaqaman et al, JCB 20104). She then joined the lab of Professor Charles Swanton at (CRICK, UK) and demonstrated a novel route to chromosome mis-segregation and chromosomal instability in cancer (Burrell* and McClelland* et al Nature 20135). Here she also contributed to work defining the concept of ‘excessive chromosomal instability’ leading to genetic meltdown of cancer cells, and better prognosis for cancer patients (Birkbak et al., Cancer Res. 20116). In 2013 she established her laboratory at the Barts Cancer Institute, Queen Mary University of London. Here, her research aims is to understand causes of chromosome mis-segregation in the context of tumourigenesis, and also to characterise fundamental mechanisms controlling genetic stability.