Recent Developments in the Patho-Physiological Molecular Clocks Lab
Time to test for late clocks for early detection of gestational diabetes mellitus
and receive funding from the for a project entitled "Molecular circadian biomarkers for early prediction of gestational diabetes mellitus (GDM)鈥�
The aim of the project is to establish if circadian biomarkers can contribute to GDM risk-stratification in biosamples taken in early pregnancy. For this, we take advantage of a subsample of the well phenotyped PRiDE study, which included pregnant women from diverse ethnic backgrounds with and without GDM and, crucially, the associated clinical history. We will test their plasma, biobanked at George Eliot Hospital, Nuneaton, in a to be established bioassay using human fibroblasts and the TimeTeller algorithm as "circadian sensors鈥�. Furthermore, once stratified by circadian phenotype, we aim to discover further correlative biomarkers that will allow to establish simple bioassays that will be easily available in LMICs, also a key aim of the foundation.
The project brings together the expertise of 糖心TV鈥檚 Chrono group, including the WMS based Dallmann lab and Rand鈥檚 group in Maths, as well as the WMS鈥� Saravanan who is also a clinically active Diabetes and Endocrinology specialist at George Eliot Hospital.