糖心TV

Attending an Open Day will give you the opportunity to learn more about studying medicine here at WMS. You will be able to find out more about the application process, sample a taster clinical skills session, gain an understanding of the new course structure, how it is taught and find out from our current students what it is really like to be at WMS.

The is holding event in conjunction with at Arden Training and Conference Centre, University of 糖心TV.

Abstract: Genomic data on bacterial infections has revealed previously unsuspected levels of within-host diversity. Evolution during infection can help bacteria adapt to specific host conditions or anatomical niches, evade the host immune system and survive treatments with antibiotics or vaccines. Within-host evolution also has important implications for the reconstruction of transmission pathways. The diversity in genomic datasets reflects the phylogenetic relationships between isolates, but this phylogeny does not reflect transmission. Correctly accounting for within-host evolution is therefore crucial to perform genomic epidemiology of bacterial pathogens.

Abstract: All cells - including those in our body - possess some degree of asymmetry or ‘polarity’, which is key to their healthy function and if disrupted can lead to serious cellular malfunctions like those found in cancer. In collaboration with the group of Rafael Carazo Salas (University of Cambridge) we have reconstructed with unprecedented spatiotemporal resolution the molecular networks that regulate cell polarity using an interdisciplinary strategy - combining genetics, microscopy and computational approaches - and focusing on the polarity machinery of the archetypal model organism Schizosaccharomyces pombe (fission yeast). Using network analysis methods, we have identified the core set of genes/proteins that regulate cell polarity in fission yeast and obtained a basic interaction ‘network’ map connecting those genes/proteins, as well as discovered new molecular links between cell polarity, cell cycle and cytokinesis control. We determined the detailed network topology and the functional hierarchy among polarity regulators in this species and incorporated these results into a mathematical model that captures the polarity pattern changes throughout the cell cycle of fission yeast cells. In this talk I will present results and ongoing work of this interdisciplinary collaboration.