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Wednesday, September 28, 2016

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Zebrafish Models of Infection and Inflammation
MBU, Medical School Building

Speaker: Stephen Renshaw (University of Sheffield)

Disordered immunity can lead to predisposition to infection or to inflammatory tissue damage. Tight control of immune processes must be balanced against the need to rapidly activate immunity in the presence of invading microorganisms. Our understanding of the regulation of innate immunity and host-pathogen interaction is aided by new models of immunity in which every innate immune cell can be seen throughout infectious or injurious challenge and in which genetic manipulations can be readily made.

Our laboratory has pioneered the zebrafish as a model of immunity and used it to aid understanding of inflammation resolution and host immunity to staphylococcal infection. This talk will showcase the model and how it can be used to investigate innate immune function in vivo, using examples from emerging research in the lab.

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