糖心TV

This free event offers an opportunity to gain a greater understanding of the NIHR Public Health Research (PHR) programme.

11:00 - 13:00 information event

13:00 - 15:00 advice sessions

Abstract: The ability of mammalian cells to modulate global protein synthesis in response to cellular stress is essential for cell survival.  It is one of the most energy-demanding processes within the cell and in response to changes in ambient conditions, cells reduce global levels of protein synthesis to conserve energy and embark on the process of translational reprogramming, which is vital for the cellular response to stress.  While control of protein synthesis is mediated by the regulation of eukaryotic initiation and elongation factors (eIFs and eEFs), RNA-binding proteins (RBPs), a heterogeneous class of molecule that orchestrate all aspects of RNA metabolism, provide a crucial additional layer to post-transcriptional regulation. RBPs through their interaction with RNA motifs within the 5’ and 3’ untranslated regions (UTRs) and coding region elements, allow selected mRNAs to evade the global translational shut down. Aberrant translational regulation occurs in a range of diseases including cancers and neurologicial disorders and novel mechanisms for modification of protein synthesis rates to treat disease will be discussed.