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Healthier and happier men make for better partners, fathers, sons

Wednesday 21 November, 10.00am - 2.30pm, A0.39 / A0.41/ A0.42 and CPD lounge (Medical School Building)

Join us at Gibbet Hill campus for a day of discussion and discovery on the topic of men's mental health and wellbeing. The programme for the day includes presentations from external speakers, local organisations and thought-provoking activities. Everyone is welcome - not just the men!

Come and join us on the 21st in the CPD lounge outside rooms A0.39, A0.41 and A0.42. Activities start at 10.00am and will carry on until 2.30pm – you, your family and your team are welcome to drop in when you can. If you'd like to come along please register for the sessions you're interested in to give us an idea of numbers.

Abstract. Many organs, such as the gut or the spine are formed through folding of an epithelium. While genetic regulations of cell fates leading to epithelium folding have been investigated, mechanisms by which forces sufficient to deform the epithelium are generated are less studied. Here we show that cells forming an epithelium onto the inner surface of spherical elastic shells protrude inward while growing. By measuring the pressure and local forces applied onto the elastic shell, we show that this folding is induced by compressive stresses arising within the epithelial layer: while growing under spherical confinement, epithelial cells are subjected to lateral compression, which induces epithelium buckling. While several fold initiations can be observed within one capsule, final shapes often show one or two folds. While analytical theory of epithelium buckling predicted a single fold at equilibrium, multicellular simulations showed several folds occurred from a competition between epithelium bending, growth and adhesion to the shell. By quantitatively comparing the shapes of buckled epithelium predicted by theory and simulations, with experimental shapes, we determined how epithelium bending rigidity, adhesion and proliferation control buckling, and extracted their values in our experimental conditions. As proposed for gastrulation or neurulation, our study shows that forces arising from epithelium proliferation are sufficient to drive epithelium folding.