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WMS Events Calendar

Please see this page for MB ChB events.

Wednesday, September 20, 2017

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Seminar: Understanding the structure and function of transcriptional repression complexes using an integrated approach, Professor John Schwabe, Leicester Institute for Structural and Chemical Biology, University of Leicester
GLT3, WMS

Abstract: My research group seeks to understand the molecular mechanisms that underlie the epigentic reprogramming of the genome during cellular differentiation and development. Our particular interest is in Histone Deacetylase (HDAC) complexes whose primary role is to remove acetyl groups from lysine sidechains within the tails of histone proteins resulting in hypo-acetylated chromatin that is the first step in gene inactivation.

There are at least six classes of HDAC-containing complexes that are targeted to chromatin. These contain the class I HDACs 1, 2 or 3 along with a variety of other proteins that target the complex to chromatin and/or possess other enzymatic activities. Importantly, the enzymatic activity of the HDACs requires assembly into these complexes.
 
We have been using a combination of X-ray crystallography, NMR spectroscopy, Small-angle X-ray Scattering, Electron microscopy, cross-linking/mass spectrometry and a range of biochemical assays to understand the assembly and regulation of these complexes.

More information | Tags: BiomedicalSciences DivisionalSeminars |
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Central Rehabilitation Network - Meeting

Speaker - Professor Pamela Enderby Title: Ensuring patients are getting the best rehabilitation

5:30pm - 6:30pm, Wed, 20 Sep '17
Location: Royal Derby Hospital

Title - "Ensuring patients are getting the best rehabilitation"

  • This is an open meeting no need to register
  • Refreshments available
  • After the meeting there will be time to network

The venue is room 7, level 3, Education centre, Royal Derby Hospital. This link shows a map of where it is in relation to the A38, nearest car park 4 and the entrance to use is number 15.

 

More information | Tags: HS_SSSH |

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