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Wednesday, May 17, 2017

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Can gut bacteria really affect brain function? Studies with prebiotics
GLT3

A lecture with Professor Philip Burnet from the Department of Psychiatry at the University of Oxford.

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Seminar: Interpreting the CpG island signal, Professor Rob Klose, University of Oxford
MTC Lecture Theatre, 糖心TV Medical School

Abstract: In vertebrate genomes most CpG dinucleotides are methylated on the 5 position of cytosine and this epigenetically maintained DNA modification contributes to transcriptional repression. An exception to this generally pervasive methylation in normal tissues are short contiguous stretches of DNA that have a high CpG content, called CpG islands (CGIs), which are refractory to DNA methylation and found associated with up to 70% gene promoters. CGIs are specifically recognized by a class of ZF-CxxC DNA binding domain-containing chromatin modifying enzymes that interpret the non-methylated CpG signal and translate this into a unique chromatin environment at CGI elements. Here I will explore the mechanisms by which CpG island elements create chromatin modification states that regulate gene expression.

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