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Thursday, November 16, 2017

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Seminar: Optogenetic dissection of sleep circuits and functions, Professor Antoine Adamantidis, Department of Neurology, University of Bern, Switzerland
MBU (A1.51), 糖心TV Medical School

Abstract: The functions of sleep are still a matter of debate and may include memory consolidation, brain clearance, anabolism and plasticity. Successive sleep-wake cycles rely on an appropriate balance between sleep-promoting nuclei of the brain located in the anterior hypothalamus and, arousal-promoting nuclei from the posterior hypothalamus and the brainstem. This lecture will present our characterisation of the hypothalamic modulation of brain structures including thalamic nuclei during wakefulness and sleep using optogenetics in combination with high-density electrophysiology in freely-behaving mice, as well as more recent data supporting a dual role for centro-medial thalamus in the propagation and modulation of cortical sleep slow waves and the role of media-dorsal thalamus in sleep recovery.

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