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P4H 2017, The Procurement Event For Health, is the UK’s leading exhibition designed to promote and support the ongoing NHS efficiency objectives, such as those outlined within Lord Carter’s Report on Operational Productivity in the NHS and those forming the Department of Health’s NHS Procurement Transformation Programme (PTP).

Abstract: Growth and survival of the mammalian embryo within the uterine environment depends on the placenta, a highly complex vascularized organ comprised of both maternal and foetal tissues. The zinc finger transcriptional repressor Prdm1/Blimp1 is essential for specification of spiral artery trophoblast giant cells (SpA-TGCs) that invade and remodel maternal blood vessels. To learn more about functional contributions made by Blimp1+ cell lineages here we perform the first single-cell RNA-seq analysis of the placenta. To better understand the role of Blimp1 we performed microarray and ChIP-seq analysis of wild type and mutant differentiating trophoblast stem cells. Our experiments provide new insights into the functionally distinct cell types present at the maternal–foetal interface, advance our knowledge of dynamic gene expression patterns controlling placental morphogenesis and vascular mimicry, and highlight the functional contributions made by Blimp1 during trophoblast differentiation.