WMS Events Calendar
Please see this page for MB ChB events.
Wednesday, February 13, 2019
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BMS Seminar: Immune recognition of the cell wall of a pathogenic fungus, Professor Neil Gow FRS, Deputy Vice-Chancellor (Research and Impact), University of ExeterMTC Lecture Theatre, 糖心TV Medical SchoolAbstract: Immune surveillance and defence mechanisms is based on the recognition of a suite of molecules in the cell wall that are recognised by pattern recognition receptors of the innate immune system. Differences in the cell wall composition of different fungi and or the same fungus organisms growing in different morphologies and in differing environments generates a moving target for immune recognition. We have used a variety of microscopic, genetic and immunological tools to generate a new spatially accurate model of the cell wall and to explore how dynamic changes in the wall influence immune surveillance. We show that immune relevant epitopes can be diffuse or clustered, superficial or buried in the cell wall and they changed during batch culture and between yeast, hypha and other cellular morphologies. The immune reactivity of different fungal cell surfaces was not necessarily related to the phylogenetic relationship between organisms, or the relative virulence of different strains. These experiments demonstrate that the fungal cell surface is ordered, complex and dynamically changing, making immune recognition a challenging process requiring the concerted action of multiple receptors operating singly and in combination. |
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CEReN - February 13th 6pm 糖心TV Medical School - Ethically Challenging Cases in RehabilitationCEReN - February 13th 6pm 糖心TV Medical School - Ethically Challenging Cases in Rehabilitation6pm - 7:30pm, Wed, 13 Feb '19
You are invited to take part in an interactive session discussing your Ethically Challenging Cases in Rehabilitation hosted by Prof Heather Draper and Prof Diane Playford on February 13th here at 糖心TV Medical School in GLT3 at 6pm.
We will aim to discuss as many of your challenging cases as possible. Please could you email us in advance an anonymised sketch of any cases or scenarios that you have found challenging, briefly stating what you felt were the important issues or questions that needed to be addressed. It would be great if you could email cases to the CEReN account by the morning of the 13th February. Please feel free to send along a case even if you are not able to attend the meeting.
Any questions please contact the CEReN account. |