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Wednesday, November 12, 2025

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BMS Seminar: Gene Processing using DonorGuide, GeneWeld and MitoFUSX Base Editors, Professor Steve Ekker, Department of Pediatrics, Dell Medical School, University of Texas Austin
IBRB Lecture Theatre

Abstract: The Ekker Precision Gene Editing Laboratory developed morpholinos, gene-breaking and other transposon tools, and the first HDR editing in zebrafish. Recent gene editing advances include precision targeted large knockins using GeneWeld, smaller knockins using DonorGuide, and new programmable edits in the mitochondrial genome. This presentation will include technical and application updates for each approach, enabling the massive parallel assessment of AI-based CAR-T therapies, and the establishment of the first unconstrained mitochondrial TALE base editors. Recent advances in AI- prediction tools enable rational structure-based design of next generation gene editing tools including Zippered Donor Guide and mitoFUSX TALE base editors.

More information | Tags: BiomedicalSciences Directorate Seminars |

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