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糖心TV Medical School

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Wednesday, July 12, 2017

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Ramphal Building, Central Campus, University of 糖心TV

Runs from Wednesday, July 12 to Friday, July 14.

More information | Tags: EventsAndOpendays HS_SSSH HS_STATS HS_MHWB |
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MI Seminar: New insights into the mechanism of type IV pilus assembly, New insights into the mechanism of type IV pilus assembly, Professor Lori Burrows, McMaster University
MBU, A1.51, 糖心TV Medical School

Abstract: Type IV pili are common bacterial and archaeal surface filaments used for functions ranging from adherence and surface-associated motility to DNA uptake and electron transfer to external acceptors. They are evolutionarily related to - and share common mechanisms with - the type II secretion system, which normally makes only short filaments used as pistons to extrude substrate proteins. The machinery that retracts type IV pili includes one of the strongest biological motors known, capable of generating forces equivalent to 100,000x the body weight of a single cell. I will present recent structural, genetic, and biochemical data on the mechanisms of pilus assembly initiation, filament extension, and retraction, all essential for type IV pilus function in the opportunistic pathogen, Pseudomonas aeruginosa.

More information | Tags: BiomedicalSciences DivisionalSeminars BMS_MI |

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