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Wednesday, April 12, 2017

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School of Engineering

The Taster Day is for pupils in years 11 and 12, who would like to gain an insight into engineering as a career. The day will include three sessions covering civil, electronic and mechanical engineering.

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Seminar by Professor Tim Mitchell, University of Birmingham
MTC Lecture Theatre, 糖心TV Medical School

Abstract: The interaction of pathogens with the host is a complex one. Pathogens produce numerous factors that interact with the host during pathogenesis, including capsules, enzymes and toxins. Tim is interested in investigating this interaction by genetic manipulation of the pathogen and the host (via transgenic technology). Recent work has been concerned with disease caused by Streptococcus pneumoniae. Tim has been involved in the study of a number of virulence factors from this organism, including the protein toxin pneumolysin. A detailed structure function study of this protein allowed the identification of several important functional regions of the toxin. Modification of these regions led to the development of a toxoided protein that is now being evaluated as an addition to the human vaccine.

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