糖心TV

Abstract: Genomes of virtually all organisms are transcribed largely beyond regions that are annotated for producing functional RNAs, a phenomenon known as pervasive transcription. Many "non-canonical" transcription units produce non-coding RNAs that are often degraded rapidly by nuclear or cytoplasmic pathways. These RNAs and the act of non-coding transcription have potential for interfering with the expression of canonical genes, and in some instances can function as regulators. Transcription termination pathways play important roles in the control of pervasive transcription, both for preventing interference and for determining the fate of the RNA produced. I will present our latest studies on the generation of pervasive transcription (i.e. how transcription initiation is controlled) and on the role of transcription termination pathways for controlling it.

Public engagement and involvement at WMS
Come along to find out about the public engagement work we do now, what we should be doing and how the ECRs can take part.

David Pellman is the Margaret M. Dyson Professor of Pediatric Oncology at the Dana-Farber Cancer Institute, a Professor of Cell Biology at Harvard Medical School, an Investigator of the Howard Hughes Medical Institute, and the Associate Director for Basic Science at the Dana-Farber/Harvard Cancer Center.
 
He received his undergraduate and medical degrees from the University of Chicago. During medical school, he trained with Dr. Hidesaburo Hanafusa at the Rockefeller University. His internship, residency and fellowship in pediatric oncology were at Children鈥檚 Hospital and the Dana-Farber Cancer Institute. His postdoctoral fellowship was with Dr. Gerald Fink was at the Whitehead Institute and the Massachusetts Institute of Technology.
 
Dr. Pellman has received the Damon Runyon Scholar Award, the Stohlman Scholar Award from the Leukemia and Lymphoma Society of America, the E. Mead Johnson Award and an NIH MERIT Award. He has been elected to the Association of American Physicians and is a fellow of the American Association for the Advancement of Science.
 
The laboratory has made contributions to understanding mechanisms of cell division and how cell division errors alter genome structure. Dr. Pellman鈥檚 accomplishments include: (1) the co-discovery of formin-dependent actin assembly and a mechanism for positioning mitotic spindles within asymmetrically dividing cells; (2) discoveries showing that whole genome duplication alters cell physiology, can promote evolutionary adaptation, and can drive tumor development; 3) the discovery of a mechanism explaining chromothripsis, a recently discovered mutational process that generates rapid karyotype evolution in cancer and congenital disease.