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糖心TV Medical School

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Thursday, March 02, 2017

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Seminar: TGFbeta signalling drives haemogenic endothelium programming and the emergence of blood stem cells, Dr Rui Monterio, Department of Medicine, University of Oxford
MBU, 糖心TV Medical School

Abstract: I am investigating the role of TGFbeta in the formation of haematopoietic stem cells (HSCs), a self-renewing multipotent progenitor population that generates and maintains all mature blood cells. HSCs arise during embryonic development from a subset of the arterial endothelium, the haemogenic endothelium, and supply blood cells throughout adult life. TGFbeta is required to programme the endothelium to become haemogenic and it does so by regulating endothelial expression of the Notch ligand Jag1a. The requirement for TGFbeta is two-fold and sequential: autocrine, via Tgfb1a and Tgfb1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfb3 from the notochord, suggesting that the former programmes the haemogenic endothelium and the latter drives the process of endothelial to haematopoietic transition. This is the first instance where TGFbeta signalling is directly implicated as a positive input in the formation of HSCs.

More information | Tags: BiomedicalSciences BMS_CDB |

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