糖心TV

Electrochemical sensor systems present an attractive route to achieving enhanced diagnosis and monitoring of healthcare conditions and for monitoring industrial processes, such as many of those employed in the energy and pharmaceutical sectors. In the group we currently develop a range of electrode systems, particularly for healthcare
applications and employ a variety of techniques, e.g. microfabrication, screen printing and the use of printed circuit
boards (PCBs) for sensor production. A strong focus has been development of microelectrode sensors for the
detection of antibiotic resistance genes (e.g. the oxacillin resistance gene oxa-1, mecA from MRSA and lytA from
Streptococcus pneumoniae), the rapid detection of protein biomarkers of sepsis (e.g. IL-6) and the detection of
multi-drug resistant TB. In addition, we are developing an assay which uses screen printed electrodes to detect circulating tumour DNA (ctDNA) in a liquid biopsy format. This will hopefully allow detection of tumours in a point
of care format and at an earlier stage when surgical resection is still a possibility. Finally, a strong theme within previous research has been the development of microfabricated microelectrode sensors for the measurement of spent nuclear fuel during reprocessing, particularly when dissolved into high temperature molten salts such as lithium-potassium eutectic. This talk will showcase all of these research themes, particularly focusing on
microfabrication techniques for producing robust devices, characterisation of electrode response and examples of sensor measurements and associated assay performance for these healthcare and energy applications.