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WMS/SLS Joint Micro Seminar: Salmonella forms intracellular persisters with TacT by Dr Sophie Helaine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London
Abstract:Persister bacteria are non-growing, antibiotic insensitive cells, the progeny of which are sensitive to antibiotics. Bacterial persistence is a common phenotype expressed by a large number of bacterial species and is thought to be responsible for relapsing infections. During Salmonella infection of macrophages an important proportion of bacteria enter a persister state via the action of class II toxin-antitoxin modules. These toxin-antitoxin modules encode a stable toxin that inhibits a vital cellular process and a labile, neutralising antitoxin, which is degraded under conditions of stress but otherwise binds and inactivates the toxin. We investigate the activity of three of these toxins, which are acetyltransferases and how bacteria recover from the persistent state.