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Seminar: Thermoresponsive materials for mammalian cell culture: a journey into the third dimension, Professor Felicity Rose, School of Pharmacy, University of Nottingham
Abstract: Felicity has led, in collaboration with Prof Cameron Alexander at Nottingham, research focussed on developing materials for enzyme-free mammalian cell culture. Starting initially in 2D, more recent research has developed this technology to a 3D platform for 3D cell culture which is now being developed as a commercial product. Illustration of the influence of a 3D culture environment on a therapeutically relevant cell type will be given in addition to further detail on her research in developing electrospun matrices for tissue engineering applications.
Biography: Dr Felicity Rose is Head of the Division of Regenerative Medicine and Cellular Therapies, School of Pharmacy at Nottingham. Felicity’s research focusses on the ability to control stem and differentiated mammalian cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models to study disease biology and for drug screening applications, with the ultimate goal of developing tissue grafts for transplantation. Felicity has expertise in materials science, controlled release of biological factors to stimulate the regenerative process, and in cell-material interactions. More specifically, she has over 8 years in experience of electrospinning polymeric materials for applications in regenerative medicine including as scaffolds to support cell and tissue growth.
She has led and participates in a portfolio of predominantly EPSRC funded proposal (also including BBSRC and NC3Rs) funded grants totalling approximately ~ £12M. She is research challenge lead within the EPSRC Programme Grant ‘Next Generation Biomaterials Discovery’ led by Prof Morgan Alexander at Nottingham, project lead for biomaterials on another EPSRC Programme Grant ‘Engineering Growth Factor Microenvironments’ led by Prof Manuel Salmeron Sanchez at Glasgow University, and is a Strand Lead within the ‘UK Regenerative Medicine Platform – Acellular Hub’ led by Prof Kevin Shakesheff. She has published over 60 peer-reviewed papers in high impact journals including Biomaterials, Advanced Materials, and PNAS.