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Speaker: Prof Marco R. Oggioni, University of Leicester

We have recently described phase variable type I restriction modification (RM) systems in the Gram-positive bacterial pathogen Streptococcus pneumoniae and reported effects of variation in methylation target specificity to relevant phenotypes. Similar phase variable systems are present in numerous bacterial species. Our current effort is to explore the functionality of these systems and elucidate the mechanism by which they influence microbial phenotypes via epigenetic modification of the host chromosome.