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Title: Mechanistic modelling of allergic diseases – From mechanisms to prediction

Abstract: In this talk, I will showcase our group’s recent works, including mechanistic modelling and machine learning/AI methods towards designing personal treatment strategies for allergic diseases (eczema, asthma). For example, we developed a mechanistic model of eczema pathogenesis which provides a coherent mechanistic explanation of the dynamic onset, progression, and prevention of eczema. The model describes triangle interactions between skin barrier, immune responses and environmental stressors. We further expanded the mechanistic models to include the effects of skin microbiome, which plays a crucial role in eczema pathogenesis. I would also like to touch on the current challenges of in silico modelling approach.

If you want to meet Reiko on Monday, please let Lukas Eigentler know.