Independent Fellows
Andrew Bowman | Chromatin Dynamics
UPDATE: We are excited to announce that Andrew has been awarded of a Sir Henry Dale Fellowship from the Wellcome-Trust and Royal Society to continue his exciting research programme
Dr. Andrew Bowman became an independent QBP fellow following postdoctoral work in the Laboratory of Andreas Ladurner (Ludwig-Maximilians-University Munich) and a PhD under the supervision of Tom Owen-Hughes (University of Dundee, UK).
Since the discovery of histone chaperones nearly four decades ago, much effort has gone into understanding how they function. The prevailing view is that histones must pass through a number of different chaperoning complexes that favour their thermodynamic incorporation into nucleosomes and prevent non-specific aggregation. To date, this has mostly been approached by looking at individual chaperones in isolation.
My goal is to accurately model the process of nucleosome assembly at the systems level by quantifying dynamic transitions that occur within the histone chaperoning pathway. This approach relies on the ability to make quantitative measurements of the histone chaperoning network in live cells using novel synthetic approaches combined with live-cell microscopy.
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email: a.bowman.1@warwick.ac.uk
Selected reading
- Pardal A.J., Fernandes-Duarte F., Bowman A.J. (2019)Essays Biochem. 63(1):29-43. (Review)
- Apta-Smith M.J., Hernandez-Fernaud JR, Bowman A.J. . EMBO J. 2018, doi: 10.15252/embj.201798714.
- Bowman A. et al., . Nucleic Acids Res. 2017, doi: 10.1093/nar/gkw892.- Bowman A. et al.,
Nucleic Acids Res. 2016, doi: 10.1093/nar/gkv1372.
- Bowman A. et al., . Nucleic Acids Res. 2014, doi: 10.1093/nar/gku232.
- Bowman A. et al.,
Molecular Cell 2011, doi: 10.1016/j.molcel.2011.01.025.
Irene Stefanini | Evolutionary Systems Biology
Dr. Irene Stefanini became an independent QBP fellow following postdoctoral work with Dr. Claudio Donati (Fondazione Edmund Mach, San Michele all'Adige, Italy) and a PhD under the supervision of Prof. Cavalieri (University of Florence, Italy).
The yeast Saccharomyces cerevisiae is one of the most studied microorganisms, used as model system to provide crucial insights into fundamental cellular processes and human diseases at the molecular level. However, research has been largely limited to a single atypical laboratory strain.
With the ever-increasing number of sequenced genomes and natural S. cerevisiae isolates I now aim to exploit the natural biodiversity to obtain insights on the predictability of phenotypic response from individual genomic sequences.
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email: i.stefanini@warwick.ac.uk
Selected reading
- Brilli M., Trabocchi A., Weil T., Cavalieri D., Stefanini I. Front. Pharmacol. 2017, doi: 10.3389/fphar.2017.00170.- Stefanini I. et al., . Proc Natl Acad Sci U S A. 2016, doi: 10.1073/pnas.1516453113.
- Stefanini I. et al., . Proc Natl Acad Sci U S A. 2012, 10.1073/pnas.1208362109.
- Stefanini I. et al., . J. Biol. Chem. 2010, doi: 10.1074/jbc.M110.125153.