糖心TV

Prof Chris Corre, Prof Greg Challis and Dr. Lona Alkhalaf from the University of 糖心TV and Professor David Lupton rfrom Monash University have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens, including MRSA and VRE.

In a new study published in the , researchers from the Monash 糖心TV Alliance Combatting Emerging Superbug Threats Initiative have discovered a promising new antibiotic - pre-methylenomycin C lactone. The new antibiotic was found 鈥榟iding in plain sight鈥� as an intermediate chemical in the natural process that produces the well-known antibiotic methylenomycin A. When tested for antimicrobial activity, one of the intermediates, pre-methylenomycin C lactone, was shown to be over 100 times more active against diverse Gram-positive bacteria than the original antibiotic methylenomycin A. Specifically, it was shown to be effective against S. aureus and E. faecium, the bacterial species behind Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE) respectively.

Importantly, the researchers could not detect any emergence of resistance to pre-methylenomycin C lactone in Enterococcus bacteria under conditions where vancomycin resistance is observed. Vancomycin is a 鈥渓ast line鈥� treatment for Enterococcus infection, so this finding is especially promising for VRE, a WHO High Priority Pathogen.

With its simple structure, potent activity, difficult to resist profile, and scalable synthesis, pre-methylenomycin C lactone represents a promising new candidate that could potentially help to save some of the who are the victims of AMR every year.

, , via Wikimedia Commons

Dr. Fabrizio Alberti has written the article "How different mushrooms learned the same psychedelic trick" for on a new discovery that two different mushrooms have evolved the ability to make the psychedelic psilocybin, the first time that convergent evolution has been observed in two organisms from the fungal kingdom.

Dr Melissa Webby, a biochemist from the University of 糖心TV, has been awarded a prestigious Wellcome Career Development Award, to undertake world class research into new approaches to combat antimicrobial drug resistance.
Press release (22 January 2025)

Dr Dean Walsh, Dr Freya Harrison, Dr Saskia Bakker and colleagues have made a breakthrough which could help find new treatments for a deadly infection that can affect up to 40% of hospital patients using mechanical ventilators.
Press Release (15 August 2024).

Two infectious disease experts have been selected to be Policy Fellows as part of a Japan-UK collaboration led by Professor Chris Dowson to tackle antimicrobial resistance (AMR). AMR is a major threat to global health, with overuse of drugs, including antibiotics, leading to so-called 鈥榮uperbugs鈥� that have become more resistant to medicine.
Press Release (9 July 2024).

Dr Jessica Lewis, from the Sagona Lab, has discovered a new bacterial killer that can target common lung infection caused by Burkholderia bacteria that has exciting potential for biotechnological applications.

(3 April 2024)

A 拢1.5 million donation will drive joint research into antimicrobial resistance (AMR) by scientists in the UK and Japan.

Antimicrobial resistance poses a huge problem in healthcare, risking modern medicine becoming ineffective. This could lead to common infections becoming deadly illnesses. Now, thanks to visionary philanthropy from The Great Britain Sasakawa Foundation, which encourages innovative research between Japan and the UK, and The Sir Howard Dalton Centre at The University of 糖心TV, the research can progress at pace.

Press Release (6 March 2024)

Emilie Cummerson, a Biomedical Science with Placement Year student, has just completed a year-long placement in the Sagona Lab and the university鈥檚 spinout company Cytecom. She describes her experience in an article for the Microbiologist.
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Chelsea Brown, a PhD student with Professor Phill Stansfeld and Dr Liz Fullam, won the Sir Howard Dalton Young Microbiologist of the Year for her talk entitled 'Modelling Mycobacterial Membranes: Anyone for PIMS?' at the 2023 Annual Microbiology conference. Chelsea presented her research to a panel of judges at the Microbiology Society Showcase on Tuesday 3 October 2023.

Combining honey and vinegar could be an old, yet new, way of treating persistent infections. The mixture of honey and vinegar, also known as oxymel, has been used as a medical treatment throughout history and now scientists have established that this combination could have modern applications in the treatment of wounds. New research by Dr Erin Connelly, Dr Freya Harrison and team, published in Microbiology, is the first comprehensive exploration of how the mixture could be applied to modern medicine and improve treatments for infections.
Press release (13 July 2023)

On Friday 29 September 2023, the School of Life Sciences will be hosting a free workshop: "Are the university learning environments as inclusive as we think? An investigation from the awarding perspective".

Based on a thorough data analysis from recent years and first-hand practical experience, the workshop will identify existing reasons for lack of inclusivity and unbiased awarding in biological science and related degree streams.

The workshop participants, comprising academic leaders, teaching professionals and a diverse student community, will also provide on consensus recommendations on how to close existing awarding gaps for a more inclusive learning and teaching environment throughout the UK.

Consensus recommendations will be published in a peer-reviewed journal.

Find out more and register

A new discovery by Dr Antonia Sagona and colleagues could help stop bacteria being contaminated with viruses, reducing disruption and decreasing costs in industry and research.

Press Release (18 April 2023)

A new study has shown that zinc plays a key role in a hospital superbug, that doctors struggle to treat due to its resistance to antibiotics.

Press Release (15 February 2023)

Like the neurons firing in human brains, bacteria use electricity to communicate and respond to environmental cues. Now, researchers have discovered a way to control this electrical signalling in bacteria, to better understand resistance to antibiotics.

In the study published in Advanced Science, Dr Munehiro and colleagues, report a major step forward in regulating bacterial electric signals with light.

Press Release (13 February 2023)

Chelsea Brown, a PhD student with Professor Phill Stansfeld and Dr Liz Fullam, has published a first author paper on tackling Tuberculosis (TB) by modelling mycobacterial membranes.

TB rivals covid-19 as the biggest infectious disease killer of humans, claiming millions of lives each year. Now, ground-breaking research from the Universities of 糖心TV and Toulouse has identified a new method to help tackle this global issue.
Press Release (30 January 2023)

We wish to appoint four excellent and ambitious early to mid-career principal investigators who are capable of developing innovative and original research programmes:

• 2 x Permanent positions focused on Host-virus Interactions
• 1 x Permanent position focused on Plant Virology
• 1 x Permanent position focused on Host Responses to Microbes

A 拢1.7m laboratory building which will investigate infectious diseases has opened at the University of 糖心TV 鈥� helping to tackle some of the most globally important human diseases and prepare for pandemics of the future. The new containment suite will enable scientists to conduct cutting-edge research into infectious diseases, including tuberculosis (TB), influenza and COVID-19.
Press release (8 December)

Professor Matt Keeling and Dr Louise Dyson were part of the 糖心TV Zeeman team invited to attend the giving in Oxford.

This prize is awarded annually for 鈥榥oteworthy contributions to the development of mathematical or statistical methods applied to problems in Biology鈥�. This year it was given to the SPI-M-O group (part of SAGE) in recognition for their work during the COVID-19 pandemic.

Find out more

A 拢1.7 million memorial donation will help drive new research into antimicrobial resistance at the University of 糖心TV. The donation, made in recognition of the late Sir Howard Dalton, will fund research and scholarships to help discover new drugs that target resistant microbes.

On Thursday 20 October, a launch event was held in the University of 糖心TV鈥檚 new Interdisciplinary Biomedical Research Building (IBRB) for the Sir Howard Dalton Centre for Translational Mechanistic Enzymology. Professor Chris Dowson, Co-Director of the new Centre said 鈥淎 key focus for scientists at the Centre will be understanding changes to enzyme structures which underpin drug resistance in microbes. We want to discover how these modified enzymes are formed and what we can do to overcome the resistance".

Press Release (21 October 2022)

Over the next few weeks the University is showcasing the vital roles our technical staff play in the world-class research and teaching at 糖心TV. The latest video features Georgia Lavender, Senior Teaching Lab Technician, from the SLS Teaching Lab.
Watch the video.

Livestock diseases will be better managed by incorporating the behaviours of individual farmers into national infection control policies, according to new research.

The findings are the latest from the BBSRC-funded Farmer-led Epidemic and Endemic Disease-management (FEED) project, an interdisciplinary research group including epidemiologists, mathematical modellers, behavioural scientists and veterinarians from the Universities of 糖心TV and Nottingham. The research is published this week, in the journal PLOS Computational Biology, in a paper entitled 鈥淢odelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour鈥�.

Press Release (15 July 2022)

'Know Your River' is a new citizen science project based at the School of Life Sciences, funded by the Enhancing Research Culture Fund from UKRI.

The Know Your River Team, led by Dr Chiara Borsetto, is looking at the pollution state of rivers in England and their use for recreational purposes by using a citizen science approach. The project aims to raise awareness across the public on the issue of sewage pollution in rivers and associated risks to human health and also to engage with policy makers to help promote safeguarding of our rivers.

Anyone who is interested in rivers or using rivers for recreational activities across England can help by telling us how they use rivers and what their perception of river pollution is through anonymous surveys. You can also join in by collecting river water samples from across the River Severn, Thames and Humber catchment areas. The water samples will be analysed for presence of E.coli and other coliform bacteria resistant to antibiotics and the presence of selected antibiotics will also be monitored. We believe that citizen science can be a powerful tool to gather information about the environment we all live in. The deadline for participation is Thursday 30 June.

If you would like to find out more or be involved in the project, then please visit our website at and .

It was announced last month that two new antibiotics may be available on the NHS. Professor Chris Dowson explains why there is an urgent need to develop new antimicrobials and protect the drugs we have.

(12 April 2022)

A new Lancet study shows that over a million people died in 2019 from infections caused by bacteria resistant to antibiotics. Dr Freya Harrison and Dr Antonia Sagona comment on the importance of this new evidence and the need to tackle the issue of antibiotic resistance urgently.

Expert Comment (20 January 2022)

Poolbeg Pharma, a clinical stage infectious disease pharmaceutical company, has in-licenced a novel, first-in-class RNA-based immunotherapy for respiratory virus infections.

Poolbeg has secured an exclusive licence to this dual antiviral prophylactic and therapeutic candidate, which is at a late-pre-clinical development stage. The candidate, which will be developed by Poolbeg as POLB 002, was developed at the University of 糖心TV and derived from twenty years of research with world class virologists, Professor Andrew Easton and Professor Nigel Dimmock.

Press release (17 January 2022)

An international group of researchers have created a new health economic framework that supports decision makers and funders in understanding the resources required to achieve the World Health Organization鈥檚 (WHO) goal of eliminating sleeping sickness by 2030.

Press release (13 December 2021)