Professor Christophe Corre

Professor

Email: c.corre@warwick.ac.uk

Phone: 024 765 23557

Office:

Twitter:

Research Clusters

Quantitative, Systems & Engineering Biology

Environment & Ecology

糖心TV Centres

糖心TV Integrative Synthetic Biology Centre (WISB)
糖心TV Antimicrobial Interdisciplinary Centre (WAMIC)
糖心TV Environmental Systems Interdisciplinary Centre (WESIC)

Vacancies and Opportunities

For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.

Research Interests

Bacterial natural products are our main subject of investigation.

We particularly interested in understanding and exploiting the regulatory mechanisms that control the production of bioactive molecules (e.g. antibiotics, agrochemicals, sunscreen agent) in actinobacteria. Our work is at the interface of chemistry and biology, it focuses on three directly related research themes:

Bacterial Transcriptional Regulators: We investigate the molecular mechanisms by which bacteria control the biosynthesis of natural products. With this aim in mind, we characterise (in vivo and in vitro) and exploit different families of transcription factors that regulate the expression of gene clusters that direct the assembly of these natural products.
Bioactive Natural Products: Our detailed understanding of such regulatory systems then opens the way to the discovery of new bioactive natural products from gene clusters which are typically silent in the laboratory environment. Indeed, we have been able to rationally inactivate specific transcriptional repressor genes and/or overexpress transcriptional activators to discover novel antibiotic-like molecules.
Biocatalysts: The structural diversity of such natural products relies on the activity of specialised/unique sets of enzymes able to assemble these complex structures. These proteins can be developed and exploited as biocatalysts for the manufacture of high value chemicals.

Research: Technical Summary

Biography

Professor, University of 糖心TV (2023 - present)
Reader, University of 糖心TV (2021 - 2023)
Associate Professor, University of 糖心TV (2015 - 2021)
Assistant Professor, University of 糖心TV (2013 - 2015)
Royal Society, University Research Fellowship (2010 - 2016)
Wellcome Trust, Value in People Research Fellowship (2009-2010)
Postdoctoral Researcher, University of 糖心TV (2004-2009)
PhD student in Chemical Biology, University of Exeter (2000 - 2004)

Publications

Corre, Christophe, Idowu, Gideon A., Song, Lijiang, Whitehead, Melanie E., Alkhalaf, Lona M. and Challis, Gregory L. (2025) Journal of the American Chemical Society, 147 (44). pp. 40554-40561. doi: ISSN 0002-7863.

Yang, Bowen, Li, Zilong, Zhang, Jingyu, Qiu, Shiwen, Liu, Xueting, Liang, Zonglin, Yan, Hao, Zhang, Yanyan, Liu, Lihong, Xia, Bing

(2025) Nature Biotechnology . doi: ISSN 1087-0156. (In Press)

Blin, Kai, Shaw, Simon, Vader, Lisa, Szenei, Judit, Reitz, Zachary L, Augustijn, Hannah E., Cediel-Becerra, Jos茅 D. D., de Cr茅cy-Lagard, Val茅rie, Koetsier, Robert A., Williams, Sam E.

(2025) Nucleic Acids Research, 53 (W1). W32-W38. gkaf334. doi: ISSN 0305-1048.

Prasongpholchai, Panward, Tucker Harvey, Sam, Burgess, Charles, Jenkins, Robert, Wilkening, Ina, Corre, Christophe, Song, Lijiang and Tosin, Manuela (2024) Chemical Communications, 60 (95). pp. 14085-14088. doi: ISSN 1359-7345.

Olumakaiye, Richard T., Corre, Christophe and Alberti, Fabrizio (2024) BMC Genomics, 25 (1). 1141. doi: ISSN 1471-2164.

Weaver, Jack A., Alkhder, Duha, Prasongpholchai, Panward, Tadesse, Micha毛l D., de los Santos, Emmanuel L. C., Song, Lijiang, Corre, Christophe and Alberti, Fabrizio (2024) ACS Chemical Biology, 19 (11). pp. 2284-2290. doi: ISSN 1554-8929.

Hymas, Michael, Wongwas, Sopida, Roshan, Simin, Whittock, Abigail L., Corre, Christophe, Omidyan, Reza and Stavros, Vasilios G. (2024) The Journal of Physical Chemistry Letters, 15 . pp. 7424-7429. doi: ISSN 1948-7185.

Waschulin, Valentin, Borsetto, Chiara, Corre, Christophe and Wellington, Elizabeth M. H. (2023) Access Microbiology, 5 (9). doi: ISSN 2516-8290.

Whittock, Abigail, Ding, Xuefei, Ramirez Barker, Xavier, Auckloo, Nazia, Sellers, Rebecca A., Woolley, Jack M., Tamareselvy, Krishnan, Vincendet, Marine, Corre, Christophe, Pickwell-MacPherson, Emma and Stavros, Vasilios G. (2023) Chemical Science, 14 (24). pp. 6763-6769. doi: ISSN 2041-6539.

Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M. and Challis, Gregory L. (2023) Nucleic Acids Research, 51 (3). pp. 1488-1499. doi: ISSN 1362-4962.

Legon, Laurence, Corre, Christophe, Bates, Declan G. and Mannan, Ahmad A. (2022) Bioinformatics, 38 (14). pp. 3657-3659. doi: ISSN 1460-2059.

Whittock, Abigail L., Woolley, Jack Matthew, Auckloo, Nazia, Corre, Christophe and Stavros, Vasilios G. (2022) Molecules, 27 (7). 2272. doi: ISSN 1420-3049.

Waschulin, Valentin, Borsetto, Chiara, James, Robert, Newsham, Kevin K., Donadio, Stefano, Corre, Christophe and Wellington, Elizabeth M. H. (2022) The ISME Journal, 16 . pp. 101-111. doi: ISSN 1751-7362.

Abiola, Temitope T., Auckloo, Nazia, Woolley, Jack Matthew, Corre, Christophe, Poigny, St茅phane and Stavros, Vasilios G. (2021) Molecules, 26 (24). e7631. doi: ISSN 1420-3049.

Whittock, Abigail L., Auckloo, Nazia, Cowden, Adam M., Turner, Matthew A. P., Woolley, Jack Matthew, Wills, Martin, Corre, Christophe and Stavros, Vasilios G. (2021) The Journal of Physical Chemistry Letters, 12 (14). pp. 3641-3646. doi: ISSN 1948-7185.

Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J. , Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., F眉l枚p, Vilmos, Challis, Gregory L. and Corre, Christophe (2021) Nature, 590 (7846). pp. 463-467. doi: ISSN 0028-0836.

Moore, Simon J., Lai, Hung-En, Chee, Soo-Mei, Toh, Ming, Coode, Seth, Chengan, Kameshwari, Capel, Patrick, Corre, Christophe, de los Santos, Emmanuel L. C. and Freemont, Paul S. (2021) ACS Synthetic Biology, 10 (2). pp. 402-411. doi: ISSN 2161-5063.

Chhun, Audam, Sousoni, Despoina, Aguilo-Ferretjans, Maria del Mar, Song, Lijiang, Corre, Christophe and Christie-Oleza, Joseph A. (2021) Microbial Biotechnology, 14 (1). pp. 291-306. doi: ISSN 1751-7907.

Zhou, Shanshan, Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2020) Chemical Communications, 56 (92). pp. 14443-14446. doi: ISSN 1364-548X.

Kaur, Divjot, Alkhder, Duha, Corre, Christophe and Alberti, Fabrizio (2020) ACS Synthetic Biology, 9 (9). pp. 2239-2245. doi: ISSN 2161-5063.

Furner-Pardoe, Jessica, Anonye, Blessing O., Cain, Ricky, Moat, John, Ortori, Catherine A., Lee, Christina, Barrett, David A., Corre, Christophe and Harrison, Freya (2020) Scientific Reports, 10 (1). 12687. doi: ISSN 2045-2322.

Alberti, Fabrizio and Corre, Christophe (2019) Natural Product Reports, 36 (9). pp. 1237-1248. doi: ISSN 0265-0568.

Alberti, Fabrizio, Leng, Daniel J., Wilkening, Ina, Song, Lijiang, Tosin, Manuela and Corre, Christophe (2019) Chemical Science, 10 (2). pp. 453-463. doi: ISSN 2041-6520.

Bowyer, Jack E., LC. de los Santos, Emmanuel, Styles, Kathryn, Fullwood, Alex, Corre, Christophe and Bates, Declan (2017) Journal of Biological Engineering, 11 (1). 30. doi: ISSN 1754-1611.

Li, Xiao, Wang, Juan, Shi, Mingxin, Wang, Weishan, Corre, Christophe and Yang, Keqian (2017) Applied Microbiology and Biotechnology, 101 (13). pp. 5333-5340. ISSN 0175-7598.

Wang, Weishan, Yang, Tongjian, Li, Yihong, Li, Shanshan, Yin, Shouliang, Styles, Kathryn, Corre, Christophe and Yang, Keqian (2016) ACS Synthetic Biology, 5 (7). pp. 765-773. doi: ISSN 2161-5063.

Sidda, John D., Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian and Corre, Christophe (2016) Organic and Biomolecular Chemistry, 14 . pp. 6390-6393. doi: ISSN 1477-0520.

Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2014) Chemical Science, Volume 5 . pp. 86-89. doi: ISSN 2041-6520.

Tang, Kunkun, Beccantini, Alberto and Corre, Christophe (2014) Computers & Fluids, 93 . pp. 74-90. doi: ISSN 0045-7930.

Song, Lijiang, Laureti, Luisa, Corre, Christophe, Leblond, Pierre, Aigle, Bertrand and Challis, Gregory L. (2014) The Journal of Antibiotics, Volume 67 (Number 1). pp. 71-76. doi: ISSN 0021-8820.

Sidda, John D., Song, Lijiang, Poon, Vincent, Al Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2013) Chemical Sciences, 5 (1). pp. 86-89. doi: ISSN 2041-6539.

Corre, Christophe (2013) Chemistry & Biology, Volume 20 (Number 2). pp. 140-142. ISSN 1074-5521 doi:

Sidda, John D. and Corre, Christophe (2012) Methods in Enzymology, 517 . pp. 71-87. doi: ISSN 0076-6879.

Aigle, Bertrand and Corre, Christophe (2012) Methods in Enzymology, Vol.517 . pp. 343-366. doi: ISSN 0076-6879.

Song, Lijiang, Laureti, L., Gomez-Escribano, J. P., Fox, David J., Yeo, V., Corre, Christophe, Huang, S., Leblond, P., Aigle, B., Bibb, M. and Challis, Gregory L. (2012) Planta Medica, Volume 78 (Number 11). Article number IL7. doi: ISSN 0032-0943.

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi: ISSN 1755-4330.

Laureti, L., Song, Lijiang, Huang, S., Corre, Christophe, Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Proceedings of the National Academy of Sciences of the United States of America, Vol.108 (No.15). pp. 6258-6263. doi: ISSN 0027-8424.

Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Journal of Bacteriology, Vol.193 (No.5). pp. 1142-1153. doi: ISSN 0021-9193.

Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2011) American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.241 (No.142-BIOL ). ISSN 0065-7727

Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Journal of the American Chemical Society, Vol.133 (No.6). pp. 1793-1798. doi: ISSN 0002-7863.

Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe and Challis, Gregory L. (2011) In: Wrigley, Stephen, (ed.) Functional Molecules from Natural Sources. Special publication (Royal Society of Chemistry (Great Britain)) (No.320). Cambridge: Royal Society of Chemistry, pp. 149-160. ISBN 9781847552594

Aigle, B., Bunet, R., Corre, Christophe, Garenaux, Am茅lie, Hotel, L., Huang, S., Laureti, L., Lautru, Sylvie, Mendes, V. M., Nezbedov谩, S., Nguyen, H., Song, Lijiang, Challis, Gregory L., Leblond, Pierre and Pernodet, Jean-Luc (2011) In: Streptomyces : molecular biology and biotechnology. [Wymondham]: Caister Academic, pp. 179-194. ISBN 9781904455776

Corre, Christophe, Haynes, Stuart W., Malet, Nicolas, Song, Lijiang and Challis, Gregory L. (2011) Chemical Communications, Vol.46 (No.23). pp. 4079-4081. doi: ISSN 1359-7345.

Corre, Christophe and Challis, Gregory L. (2010) In: Mander, Lewis N. and Liu, Hung-wen, 1952-, (eds.) Comprehensive natural products II : chemistry and biology. Amsterdam ; Boston: Elsevier, pp. 429-453. ISBN 9780080453828

Corre, Christophe and Challis, Gregory L. (2009) Natural Product Reports, Vol.26 (No.8). pp. 977-986. ISSN 0265-0568 doi:

O'Rourke, S. (Sean), Wietzorrek, Andreas, Fowler, Kay, Corre, Christophe, Challis, Gregory L. and Chater, K. F. (2009) Molecular Microbiology, Vol.71 (No.3). pp. 763-778. doi: ISSN 0950-382X.

Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi: ISSN 1044-0305.

Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F. and Challis, Gregory L. (2008) Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17510-17515. doi: ISSN 0027-8424.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi: ISSN 1074-5521.

Corre, Christophe and Challis, Gregory L. (2007) Chemistry & Biology, Volume 14 (Number 1). pp. 7-9. ISSN 1074-5521 doi:

Song, Lijiang, Barona-Gomez, Francisco, Corre, Christophe, Xiang, Longkuan, Udwary, Daniel W., Austin, Michael B., Noel, Joseph P., Moore, Bradley S. and Challis, Gregory L. (2006) Journal of the American Chemical Society, 128 (46). pp. 14754-14755. doi: ISSN 0002-7863.

Walton, Laura J., Corre, Christophe and Challis, Gregory L. (2006) In: Joint 8th Symposium on the Genetics and Molecular Biology of Industrial Microorganisms/8th International Conference on Biotechnology of Microbial Products, San Diego, USA, 14-18 Vov2004. Published in: Journal of Industrial Microbiology and Biotechnology, Volume 33 (Number 2). pp. 105-120. doi: ISSN 1367-5435.

Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe and Challis, Gregory L. (2006) Chemical Communications (Number 38). pp. 3981-3983. doi: ISSN 1359-7345.

Corre, Christophe and Challis, Gregory L. (2005) Chembiochem, Volume 6 (Number 12). pp. 2166-2170. doi: ISSN 1439-4227.

Research Projects

Title	Funder	Award start	Award end
Conditions of use agreement with University of Tubingen for bacterial strain	Universitat T眉bingen	01 July 2021	30 June 2024
SIMBA: signal Propagation and Information in Microscale Biological Applications	EPSRC	01 May 2021	31 October 2023
BBSRC Mid-range Equipment ALERT 2021 Application - November 2021	BBSRC	01 August 2022	31 July 2023
Terahertz skinometer for improved cancer prevention and treatment	EPSRC	01 April 2019	31 December 2022
Early Career Fellowship costed extension for Dr Fabrizio Alberti (linked to Ideate 58035 Engineering a yeast cell factory for production of valuable meroterpenoids)	Leverhulme Trust	01 November 2021	31 January 2022
Combatting Antimicrobial Resistance Training Network	European Commission	01 January 2018	31 December 2021
Developing a Cell Free Transcription-Translation Engineering Platform for Natural Product Research. iCASE studentship with Syngenta under Synbio CDT	Syngenta Ltd	25 November 2018	24 November 2021
Engineering a yeast cell factory for production of valuable meroterpenoids. Early Career Fellowship for Dr Fabrizio Alberti	Leverhulme Trust	01 November 2018	31 October 2021
19 Alert mid-range Equipment Initiative: equipment to upgrade the 600 NMR console at the NMR facility.	BBSRC	01 November 2020	31 March 2021
糖心TV Integrative Synthetic Biology Centre (WISB)	BBSRC	14 November 2014	31 May 2020
Novel inducible gene expression systems based on furan inducers and the MmfR transcriptional rerpessor	BBSRC	01 June 2015	30 April 2019
Genome mining of marine bacteria for novel bioactive natural products 2016 China NSFC Costshare	Royal Society	01 March 2017	30 March 2019
16ALERT: Mid-Range Equipment Initiative: A high sensitivity triple quadruple mass spectrometer coupled to an ultra-high pressure liquid chromatograph system for quantitative analysis	BBSRC	01 July 2017	30 June 2018
Discovery of antimicrobials active against Clostridium difficile from actinomycete gene clusters. MLSRF bursary for Dr Fabrizio Alberti	Medical and Life Sciences Research Fund	01 June 2017	30 November 2017
Developing World Scholarship for Attah Francis Alfred Unuagbe: Characterising and exploiting putative antimicrobial cyclotides from Rinorea dentata used in Nigerian ethnomedicine	Royal Society of Chemistry	01 October 2016	31 December 2016
Characterising and exploiting cyclotides from Nigerian ethnomedicinal plants	EPSRC	01 August 2016	01 December 2016
Establishing the potential of biosynthetic urea-synthetases as industrial biocatalysts	BBSRC	01 May 2016	31 October 2016
Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics	BBSRC	01 September 2013	30 September 2016
New Chemical Keys to unlock microbial antibiotics- University Research Fellowship (supplement)	Royal Society	10 April 2014	30 September 2015
New Chemical Keys to unlock microbial antibiotics- URF (Supplemental)	Royal Society	22 February 2013	30 September 2015
New Chemical Keys to unlock microbial antibiotics- URF (Supplemental)	Royal Society	25 January 2012	30 September 2015
New Chemical Keys to unlock microbial antibiotics- University Research Fellowship	Royal Society	01 October 2010	30 September 2015
New Chemical Keys to unlock microbial antibiotics- University Research Fellowship	Royal Society	01 October 2010	30 September 2015
Co-crystallisation of transcriptional repressors and synthetic oligonucleotides	Royal Society	01 April 2012	31 March 2014
New Chemical Keys to unlock microbial antibiotics- URF (Supplemental)	Royal Society	21 November 2011	30 September 2012
International travel grant- Chemistry and Health	Royal Society	04 June 2011	10 June 2011
Elucidation of the Unusual Methylenomycin Biosynthetic Pathway in Streptomyces Coelicolor.	BBSRC	01 July 2006	30 June 2009

Teaching / Student Supervision

Chris is the Director of Postgraduate Research in the School of Life Sciences. He teaches on the following modules: Beyond Science: Collaborative Student-Led Challenges (CH169); Enzymology (LF208); Tools for Biochemical Discovery Laboratories (LF219); Advanced Chemical Biology (CH411).

I am happy to receive enquiries about Research projects in my group (at undergraduate, postgraduate or postdoctoral level), please contact me at the above email address.

Y3 UG projects are available to students who want to work in the field of bacterial natural products (e.g. antibiotics, agrochemicals, sunscreen agents), encompassing microbiology and analytical chemistry.