糖心TV

The latest research into the use of biomaterials to increase the availability of donor cells has been . Donor cells (e.g blood, bone marrow) are crucial to modern healthcare but due to their short shelf life they must be frozen using organic solvents as 'antifreezes'. The Gibson group has pionnered the use of synthetic polymers which inhibit ice crystal growth and their application to cryopreservation. In this work, a collaboraiton with the team used biomimetic block copolymer micelles to provide a hydrated 'matrix' around the cells, which in combination with ice inhibiting polymers enable succesful cryopreservation of red blood cells. This is the first example of a cryopreservation system using entirely synthetic polymer materials, providing control and additional functionality into the system. Post-thawing, the micelles warm up, and become 'worm-like' which enabled the direct formation of a hydrogel, which is of interest for tissue engineering.

Read the paper here

investigates the influence of different intermolecular interactions on protein dynamics. The paper presents first ever extensive site-specific relaxation measurements on a large non-crystalline protein-antibody complex in a few nanomole quantities. The study paves the way for direct characterization of dynamics in biologically important but sensitivity-limited samples of proteins within large complexes.

糖心TV Chemistry, Life Science and Medical School team up to make a new generation of readily self-assembled metallohelices kill cancer cells at very low concentration (40 nM) but have low toxicty to microbes, insects and healthy human cells.

A recent paper by the in Chem Commun has been highlighted in the RSC Magazine 'Chemistry World'. The Gibson Group have a research program focussed on mimicking the function of Antifreeze Proteins which are found in Polar fish species. These proteins can slow the rate of ice growth, which has been identified as a challenge in the cryopreservation of donor cells and tissue for transplantation. In this work they showed a facile route to new cryoprotective polymers, using cheap, commodity polymer starting materials. These polymers were shown to have ice growth inhibition activity and to signficantly reduce the ice-induced damage during red blood cell freeze/thaw storage. In a second paper, the group also reported signficantly enhanced cryopreservation using poly(vinyl alcohol).

Read the Chemical Communications article here;

Read our recent ACS Biomaterials Science and Enginneering paper here

Józef Lewandowski was awarded "for his outstanding accomplishments to date and his promise in the development of solid-state NMR methodology and its application to the study of biomolecular structure and dynamics." The prize will be presented during ISMAR Conference in Shanghai.

At the Chemistry Departments annual postgraduate symposium, Robert Deller () and Athina anastasaki () won the prizes for the best PhD Theses. The Thesis prize is Sponsored by the Faculty of Science.

The and groups are involved in 2 new projects intended to promote translation of new technologies. These projects are funded by the Industrial Biocatalyst program supported by Innovate UK, BBSRC and EPSRC and span a range of UK universities and companies.

Dr Matthew Gibson has been awarded the RSC/Dextra Medal for Carbohydrate Science. This award, which is sponsored by Dextra Laboratories, was founded in 1970. It is presented to a scientist in the early/mid stage of their career for meritorious work in carbohydrate chemistry that has largely been conducted in the UK.

Matt will present a lecture, and recieve the medal at the joint RSc/COST MultiglycoNano Meeting in Bangor, Wales, in April.

3 Academics in the Department have been awarded prestigious ERC starting grants with a total value of almost €5 million. Set up in 2007 by the EU, the European Research Council (ERC) is the first pan-European funding organisation for frontier research. It aims to stimulate scientific excellence in Europe by encouraging competition for funding between the very best, creative researchers of any nationality and age.

will develop new synthetic methodology for studying the interaction of alkanes with transition metals.
will study mimics of antifreeze (glyco)proteins with the aim of improving cell cryopreservation.
will develop and apply approaches to investigate structural dynamics of large protein complexes by solid- and solution-state NMR.

These awards bring the total number of ERC-funded researches in the Department to 8, a clear testament to the internationally-leading nature of the research environment at 糖心TV.

Lewandowski group in collaboration with Grzesiek (Basel, Switzerland) and Samoson (Tallinn, Estonia) groups has introduced a new solid-state NMR based approach that enables quantitative structural and dynamics studies of large protein complexes in a few nanomole quantities. This manuscript signifying a dawn of new era for high resolution NMR studies of large protein complexes has been featured in JACS Spotlights. .

The recent work on antifreeze-protein mimics has been highlighted on the front cover of RSC Biomaterials Science. http://pubs.rsc.org/en/content/articlelanding/2014/bm/c4bm00153b#!divAbstract

Cryopreservation research has been highlighted in an article in Chemical and Engineering News. The group are developing a range of macromolecules which mimic the function of antifreeze proteins, found in Polar fish species, which can slow the rate of ice crystal growth. The group have shown these unique polymers to enhance the cryopreservation of donor tissue/cells, particulary blood. (Image is ice crystals which are inhibited by the polymers) and also the (login required).

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