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BEGIN:VEVENT
DTSTAMP:20260426T043449Z
DTSTART;VALUE=DATE-TIME:20260429T131500
DTEND;VALUE=DATE-TIME:20260429T141500
SUMMARY:BMS Seminar: Professor Kristian Franze\, Department of Physiology
 \, Development and Neuroscience University of Cambridge
TZID:Europe/London
UID:20260429-8ac672c49a2faca3019a356c61132af6@warwick.ac.uk
CREATED:20260415T074503Z
DESCRIPTION:
LOCATION:MTC Lecture Theatre \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260415T074503Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260426T043449Z
DTSTART;VALUE=DATE-TIME:20260715T131500
DTEND;VALUE=DATE-TIME:20260715T141500
SUMMARY:BMS Seminar: Professor Scott Waddell\, Department of Physiology\,
  Anatomy and Genetics\, University of Oxford
TZID:Europe/London
UID:20260715-8ac672c49a915c0d019aa11607ba1f5b@warwick.ac.uk
CREATED:20251120T114704Z
DESCRIPTION:
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20251120T114704Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260426T043449Z
DTSTART;VALUE=DATE-TIME:20260605T131500
DTEND;VALUE=DATE-TIME:20260605T141500
SUMMARY:BMS Seminar: Collective state transitions in epithelial dynamics 
 through mechanochemical feedback\, Dr Tsuyoshi Hirashima\, Mechanobiolog
 y Institute/Department of Physiology\, National University of Singapore
TZID:Europe/London
UID:20260605-8ac672c49d3cb3aa019d4d41606f64d7@warwick.ac.uk
CREATED:20260402T082206Z
DESCRIPTION:Abstract: Collective cell motion is a fundamental phenomenon 
 at the interface of cell biology\, developmental biology\, and non-equil
 ibrium physics. However\, how mechanical and chemical cues are integrate
 d at the cellular level to generate coordinated multicellular behaviours
  remains incompletely understood. In this talk\, I will present a mechan
 o-signalling feedback mechanism that couples ERK activity with mechanica
 l force generation and cell movement\, giving rise to robust spatiotempo
 ral coordination observed both in vitro and in vivo. I will first review
  prior work establishing ERK-mediated feedback as a prototypical example
  of an active epithelial system\, in which biochemical signalling and me
 chanics are dynamically intertwined. Building on this framework\, I will
  then introduce our recent findings that reveal two distinct but coupled
  types of transitions governing collective dynamics: a rigidity transiti
 on\, which modulates the mechanical state of the tissue\, and a percolat
 ion transition\, which controls the connectivity required for long-range
  signal propagation. I will discuss how the interplay between these tran
 sitions defines the dynamical regimes of epithelial tissues and enables 
 the emergence of coordinated patterns of activity. Biography: Tsuyoshi H
 irashima was trained as a mathematical biologist and received his Ph.D. 
 from Kyushu University in 2011. During his Ph.D. training\, he studied m
 athematical modeling on tissue morphogenesis in development under the me
 ntorship of Prof. Yoh Iwasa. He moved to Kyoto University as a JSPS post
 doc research fellow and learned experimental skills in cell and developm
 ental biology at Prof. Ryoichiro Kageyama’s lab. He then joined the facu
 lty of Kyoto University as an Assistant Professor in 2014\, a senior lec
 turer in 2017\, and an Associate Professor at the Hakubi Center for Adva
 nced Research in 2021. He has since joined MBI in 2022 to further pursue
  his scientific and personal curiosity. He has been on the editorial boa
 rd of Journal of Theoretical Biology since 2022.
LOCATION:MTC Lecture Theatre \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260402T082206Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260426T043449Z
DTSTART;VALUE=DATE-TIME:20260422T131500
DTEND;VALUE=DATE-TIME:20260422T141500
SUMMARY:BMS Seminar: Pierced ears and ear rings: Epithelial fusion and fr
 acture in the developing zebrafish inner ear\, Professor Tanya Whitfield
 \, School of Biosciences\, University of Sheffield
TZID:Europe/London
UID:20260422-8ac672c59a9c0398019aa0f66f131a4d@warwick.ac.uk
CREATED:20260420T094150Z
DESCRIPTION:Abstract: Epithelial fusion and fracture events are critical 
 for the generation of shape and form during organogenesis in the develop
 ing embryo. Failure of epithelial fusion can result in congenital anomal
 ies such as spina bifida\, cleft palate and ocular coloboma. In this tal
 k\, I will present work on epithelial remodelling events during semicirc
 ular canal morphogenesis in the zebrafish ear\, involving the outgrowth\
 , fusion and perforation of pairs of epithelial projections to form cont
 inuous pillars of tissue. We use live fluorescence imaging of transgenic
  wild-type and mutant zebrafish embryos to study this process. Epithelia
 l fusion in the ear is critically dependent on the mechanosensitive adhe
 sion G protein-coupled receptor Adgrg6 (Gpr126). Signalling through this
  receptor is both required and sufficient for changes in gene expression
  and cell behaviour at the fusion plate\, a transient epithelial bilayer
 . Our data illuminate both generic and inner-ear-specific requirements f
 or epithelial fusion and fracture during morphogenesis of a sensory orga
 n. Biography: Tanya Whitfield completed her PhD at the University of Cam
 bridge\, and undertook postdoctoral work in Cambridge\, Oxford\, Tübinge
 n and London. She established a research group at the University of Shef
 field in 1997\, where she is now Professor of Developmental Biology. The
  Whitfield lab has broad interests in the development of vertebrate sens
 ory organs\, including the inner ear\, lateral line and olfactory system
 . We use the zebrafish embryo as a model system\, exploiting its superb 
 advantages for live imaging\, together with genetic and pharmacological 
 perturbation of protein function. Our work aims to identify and explore 
 the mechanisms that generate shape and form from sheets of cells in the 
 developing vertebrate embryo\, and to identify and characterise rare cel
 l types. We also use the zebrafish as a model system to understand human
  disease\, and as a platform for drug discovery.
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260420T094150Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
BEGIN:VEVENT
DTSTAMP:20260426T043449Z
DTSTART;VALUE=DATE-TIME:20260617T131500
DTEND;VALUE=DATE-TIME:20260617T141500
SUMMARY:BMS Seminar: Dr Kate McDole\, MRC Laboratory of Molecular Biology
 \, University of Cambridge
TZID:Europe/London
UID:20260617-8ac672c69a9158c4019aa104a0963e0a@warwick.ac.uk
CREATED:20251120T112706Z
DESCRIPTION:
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
URL:
ATTACH:
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20251120T112706Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
END:VCALENDAR