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BEGIN:VEVENT
DTSTAMP:20260503T183326Z
DTSTART;VALUE=DATE-TIME:20250814T133000
DTEND;VALUE=DATE-TIME:20250814T143000
SUMMARY:Cellular Interfaces Seminar: Blebes in cell signalling and cancer
  disease progression\, Dr Ankita Jha\, NIH Bethesda
TZID:Europe/London
UID:20250814-8ac672c7987b51140198894d4dfa32ea@warwick.ac.uk
CREATED:20250808T105149Z
DESCRIPTION:Abstract: Blebs are dynamic membrane protrusions increasingly
  recognized as active regulators of signaling and cell behavior. In this
  talk\, I will present how bleb morphology organizes intracellular signa
 ling to drive migration in metastatic melanoma\, particularly under conf
 ined\, low-adhesion environments. Unlike mesenchymal migration\, bleb-ba
 sed motility relies on large\, pressure-driven leader blebs that define 
 cell polarity. Using high-resolution live imaging\, molecular perturbati
 ons\, and optogenetics\, we show that growth factor receptor-PI3K signal
 ing is essential for maintaining a stable\, polarized bleb. We further i
 dentify that CD44 and membrane-cortex linkers restrict receptor mobility
  on the plasma membrane at the bleb rear\, supporting a spatial signalin
 g gradient crucial for persistent migration. Our combined experimental a
 nd modeling approaches reveal a feedback loop between cortical architect
 ure and signaling\, establishing a novel polarity axis. These findings h
 ighlight how membrane organization enables migratory plasticity\, allowi
 ng tumor cells to adapt to physical constraints during metastasis. This 
 work also underscores how distinct spatial arrangements of conserved sig
 naling modules on the membrane enable plasticity in migration strategies
 \, allowing metastatic cells to adapt to biophysical constraints of the 
 tumor microenvironment.
LOCATION:MRI\, SLS
CATEGORIES:BiomedicalSciences,Cellular Interfaces Seminar,Directorate Sem
 inars
LAST-MODIFIED:20250808T105149Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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