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BEGIN:VEVENT
DTSTAMP:20260504T081820Z
DTSTART;VALUE=DATE-TIME:20250114T120000
DTEND;VALUE=DATE-TIME:20250114T130000
SUMMARY:WMS and SLS Microbiology and Infectious Diseases Seminar: Learnin
 g the RNA Jigsaw Rules from Viruses with Multi-segmented Genomes\, Dr Al
 ex Borodavka\, Department of Chemical Engineering and Biotechnology\, Un
 iversity of Cambridge
TZID:Europe/London
UID:20250114-8ac672c7943eeefe01944028c57006e4@warwick.ac.uk
CREATED:20250107T104928Z
DESCRIPTION:Abstract: A crucial step in viral replication is the formatio
 n of specialised organelles known as viral factories\, or viroplasms. Th
 ese cytoplasmic granules supporting viral replication are thought to be 
 formed through phase separation (PS) of viral proteins and RNAs. We have
  shown that rotavirus viroplasms are ribonucleoprotein (RNP) granules\, 
 originating from the PS of non-structural proteins that orchestrate viro
 plasm formation\, and accumulate eleven distinct types of viral RNA tran
 scripts that will form the complete eleven-segmented rotavirus genome. W
 e have developed an in vitro system that mimics the behaviour of these v
 iroplasmic condensates\, capable of incorporating both single-stranded a
 nd double-stranded RNAs\, as well as the viral RNA-dependent RNA polymer
 ase. Using high-throughput analytical microfluidics\, machine learning t
 echniques\, and microscopy\, we explore phase transitions and maturation
  of viroplasms aiming to uncover their role in rotavirus replication\, a
 nd the assembly of its eleven-segmented RNA genome. Our work sheds light
  on the mechanisms\, by which viral factories selectively accumulate vir
 al transcripts required for segmented genome packaging. We propose that 
 these processes are required for the stoichiometric assembly and replica
 tion of the segmented viral RNA genome\, highlighting the emergent prope
 rties of condensates in supporting viral replication.
LOCATION:A041\, Medical School Building
URL:/fac/sci/lifesci/intranet/staffpg/diary/mids
ATTACH:/fac/sci/lifesci/intranet/staffpg/diary/mids
CATEGORIES:BiomedicalSciences,SLS/WMS Microbiology and Infectious Disease
  seminar,Directorate Seminars
LAST-MODIFIED:20250107T104928Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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