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BEGIN:VEVENT
DTSTAMP:20260502T062352Z
DTSTART;VALUE=DATE-TIME:20260402T120000
DTEND;VALUE=DATE-TIME:20260402T130000
SUMMARY:BMS Seminar: Common allele and yet a large effect? Professor Miha
 ela Pavlicev\, Department of Evolutionary Biology\, University of Vienna
 
TZID:Europe/London
UID:20260402-8ac672c69cd0c4b2019cd1bc6cac006b@warwick.ac.uk
CREATED:20260309T083512Z
DESCRIPTION:Abstract: In this talk\, I would like to discuss our work exp
 loring the effects of a mutation at the Wnt4 locus. This common human SN
 P has been repeatedly associated with antagonistic pleiotropic effects o
 n pregnancy length and endometriosis\, among other reproductive phenotyp
 es. We showed previously that the minor allele is known to generate a no
 vel perfect binding site for estrogen receptor alpha. Using transgenic m
 ouse lines with this mutation\, we showed that it causes upregulation of
  Wnt4 expression in mouse endometrial stromal cells following the preovu
 latory estrogen peak. Notably\, the pregnancy length in these mice is no
 t affected. However\, together with upregulation of Wnt4 in mutants\, we
  see a series of phenotypes that suggest an effect on implantation\, and
  appear at odds with previous findings that endometriosis is associated 
 with diminished progesterone response. I will discuss the published work
 \, as well as some of the more recent findings. Biography: Mihaela Pavli
 cev is Professor for Theoretical Evolutionary Biology at the University 
 of Vienna. Her studies led her from a PhD in Ecology at the University o
 f Vienna\, over postdoctoral positions in Evolutionary Quantitative Gene
 tics in St. Louis (USA) and Oslo (Norway)\, to a research professorship 
 at Cincinnati Children’s Hospital Research Center in 2013. During the la
 tter\, her work increasingly focused on the genetic basis of mammalian r
 eproductive traits\, among which pregnancy length featured strongly. In 
 2019\, Pavlicev returned to Vienna to take on her current position. In h
 er research\, she addresses the genetic bases and the evolution of repro
 ductive traits.
LOCATION:IBRB Lecture Theatre
URL:
ATTACH:
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260309T083512Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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