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BEGIN:VEVENT
DTSTAMP:20260503T043651Z
DTSTART;VALUE=DATE-TIME:20260225T131500
DTEND;VALUE=DATE-TIME:20260225T141500
SUMMARY:BMS Seminar: Functional genomics of human immune responses in tub
 erculosis\, Professor Mahdad Noursadeghi\, Professor of Infectious Disea
 ses\, Division of Infection and Immunity\, University College London
TZID:Europe/London
UID:20260225-8ac672c69a2fa983019a3526396a12ef@warwick.ac.uk
CREATED:20260206T100538Z
DESCRIPTION:Abstract: Tuberculosis ranks amongst the commonest infectious
  disease causes of death. We aim to unlock greater understanding of the 
 immunological determinants of protection and pathogenesis in tuberculosi
 s (TB)\, in order to stratify disease-risk following infection with Mtb 
 or to develop a more effective vaccine than BCG. We have leveraged funct
 ional genomic investigation of the 100-year-old tuberculin skin test as 
 a standardised experimental challenge to model human in vivo immune resp
 onses in TB. These studies have identified immunological pathways as pot
 ential therapeutic targets to ameliorate immunopathogenesis of disease\,
  identification of genetic determinants of immune response variation\, a
 nd introduce an antigen-agnostic approach to identify generalisable T ce
 ll responses as novel correlates of outcome. Biography: I am a Clinician
  Scientist in Infectious Disease at University College London (UCL) and 
 an Honorary Consultant at University College London Hospitals (UCLH) NHS
  Trust. I am Director of the UCL Division of Infection and Immunity\, an
 d UCL Wellcome Clinical PhD program\, and I co-lead the Infection\, Immu
 nopathology and Immunotherapeutics Theme in the National Institute for H
 ealth Research (NIHR) Biomedical Research Centre at UCLH. I undertake ba
 sic science and clinical research on host‑microbial interactions to inve
 stigate the pathogenesis of infectious diseases focussing on tuberculosi
 s and respiratory viruses. We aim to develop novel approaches for diagno
 sis\, patient stratification\, and identification of new targets for the
 rapeutic intervention. My research is funded by the Wellcome Trust\, Med
 ical Research Council\, NIHR and Coalition for Epidemic Preparedness Inn
 ovations (CEPI).
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260206T100538Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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