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BEGIN:VEVENT
DTSTAMP:20260502T063842Z
DTSTART;VALUE=DATE-TIME:20260422T131500
DTEND;VALUE=DATE-TIME:20260422T141500
SUMMARY:BMS Seminar: Pierced ears and ear rings: Epithelial fusion and fr
 acture in the developing zebrafish inner ear\, Professor Tanya Whitfield
 \, School of Biosciences\, University of Sheffield
TZID:Europe/London
UID:20260422-8ac672c59a9c0398019aa0f66f131a4d@warwick.ac.uk
CREATED:20260420T094150Z
DESCRIPTION:Abstract: Epithelial fusion and fracture events are critical 
 for the generation of shape and form during organogenesis in the develop
 ing embryo. Failure of epithelial fusion can result in congenital anomal
 ies such as spina bifida\, cleft palate and ocular coloboma. In this tal
 k\, I will present work on epithelial remodelling events during semicirc
 ular canal morphogenesis in the zebrafish ear\, involving the outgrowth\
 , fusion and perforation of pairs of epithelial projections to form cont
 inuous pillars of tissue. We use live fluorescence imaging of transgenic
  wild-type and mutant zebrafish embryos to study this process. Epithelia
 l fusion in the ear is critically dependent on the mechanosensitive adhe
 sion G protein-coupled receptor Adgrg6 (Gpr126). Signalling through this
  receptor is both required and sufficient for changes in gene expression
  and cell behaviour at the fusion plate\, a transient epithelial bilayer
 . Our data illuminate both generic and inner-ear-specific requirements f
 or epithelial fusion and fracture during morphogenesis of a sensory orga
 n. Biography: Tanya Whitfield completed her PhD at the University of Cam
 bridge\, and undertook postdoctoral work in Cambridge\, Oxford\, Tübinge
 n and London. She established a research group at the University of Shef
 field in 1997\, where she is now Professor of Developmental Biology. The
  Whitfield lab has broad interests in the development of vertebrate sens
 ory organs\, including the inner ear\, lateral line and olfactory system
 . We use the zebrafish embryo as a model system\, exploiting its superb 
 advantages for live imaging\, together with genetic and pharmacological 
 perturbation of protein function. Our work aims to identify and explore 
 the mechanisms that generate shape and form from sheets of cells in the 
 developing vertebrate embryo\, and to identify and characterise rare cel
 l types. We also use the zebrafish as a model system to understand human
  disease\, and as a platform for drug discovery.
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260420T094150Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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