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BEGIN:VEVENT
DTSTAMP:20260503T214847Z
DTSTART;VALUE=DATE-TIME:20260128T131500
DTEND;VALUE=DATE-TIME:20260128T141500
SUMMARY:BMS Seminar: A Jedi and a Chosen One: GATA6⁺ Cavity Macrophages a
 nd the Divergent Repair Outcomes of Monocyte-Derived Cells\, Professor J
 oel Zindel\, Institute of Molecular Health Sciences\, ETH Zurich
TZID:Europe/London
UID:20260128-8ac672c59a711560019a824e66c2331f@warwick.ac.uk
CREATED:20260123T124101Z
DESCRIPTION:Abstract: Body cavities are an evolutionarily conserved archi
 tectural feature of metazoans: fluid-filled spaces in which organs are s
 uspended\, allowed to move\, and mechanically interact to fulfill their 
 function. These same spaces harbor a primordial\, highly specialized imm
 une ecosystem. Among its most striking components are cavity-resident ma
 crophages\, which exist in suspension within the serous fluid. Positione
 d for constant surveillance\, they sense deviations from homeostasis wit
 hin minutes and initiate broad\, pleiotropic responses that shape the en
 suing inflammatory trajectory. Using intravital microscopy\, we have unc
 overed new principles of the biology of these cavity macrophages—how the
 y patrol\, how they respond to micro-injury\, and how rapidly they can b
 e depleted. Their depletion\, classically observed as “macrophage disapp
 earance” from the peritoneal fluid\, marks a critical threshold: once re
 sident macrophages are spent\, secondary waves of immune cells such as n
 eutrophils and monocytes are recruited. These monocytes\, in turn\, diff
 erentiate into non-resident macrophages with distinct phenotypes and fun
 ctions. I will discuss how these macrophage populations and mesenchymal 
 cells cooperate during inflammation and resolution\, and how their divis
 ion of labor ultimately influences tissue repair within serous environme
 nts. Biography
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260123T124101Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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