BEGIN:VCALENDAR
PRODID:-//SiteBuilder 2//University of ÌÇÐÄTV ITS Web Team//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-TIMEZONE:Europe/London
X-LIC-LOCATION:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
LAST-MODIFIED:20201010T011803Z
TZURL:http://tzurl.org/zoneinfo/Europe/London
X-LIC-LOCATION:Europe/London
X-PROLEPTIC-TZNAME:LMT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+000115
TZOFFSETTO:+0000
DTSTART:18471201T000000
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19160521T020000
RDATE:19170408T020000
RDATE:19180324T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210403T020000
RDATE:19220326T020000
RDATE:19230422T020000
RDATE:19240413T020000
RDATE:19270410T020000
RDATE:19300413T020000
RDATE:19330409T020000
RDATE:19340422T020000
RDATE:19350414T020000
RDATE:19380410T020000
RDATE:19390416T020000
RDATE:19400225T020000
RDATE:19460414T020000
RDATE:19470316T020000
RDATE:19480314T020000
RDATE:19490403T020000
RDATE:19530419T020000
RDATE:19540411T020000
RDATE:19570414T020000
RDATE:19600410T020000
RDATE:19680218T020000
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19161001T030000
RDATE:19170917T030000
RDATE:19180930T030000
RDATE:19190929T030000
RDATE:19201025T030000
RDATE:19211003T030000
RDATE:19221008T030000
RDATE:19391119T030000
RDATE:19471102T030000
RDATE:19481031T030000
RDATE:19491030T030000
RDATE:19711031T030000
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19230916T030000
RRULE:FREQ=YEARLY;UNTIL=19240921T020000Z;BYMONTH=9;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19250419T020000
RRULE:FREQ=YEARLY;UNTIL=19260418T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19251004T030000
RRULE:FREQ=YEARLY;UNTIL=19381002T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19280422T020000
RRULE:FREQ=YEARLY;UNTIL=19290421T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19310419T020000
RRULE:FREQ=YEARLY;UNTIL=19320417T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19360419T020000
RRULE:FREQ=YEARLY;UNTIL=19370418T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BDST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19410504T020000
RDATE:19450402T020000
RDATE:19470413T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19410810T030000
RRULE:FREQ=YEARLY;UNTIL=19430815T010000Z;BYMONTH=8;BYMONTHDAY=9,10,11,12,
 13,14,15;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BDST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19420405T020000
RRULE:FREQ=YEARLY;UNTIL=19440402T010000Z;BYMONTH=4;BYMONTHDAY=2,3,4,5,6,7
 ,8;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19440917T030000
RDATE:19450715T030000
RDATE:19470810T030000
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19451007T030000
RRULE:FREQ=YEARLY;UNTIL=19461006T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19500416T020000
RRULE:FREQ=YEARLY;UNTIL=19520420T020000Z;BYMONTH=4;BYMONTHDAY=14,15,16,17
 ,18,19,20;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19501022T030000
RRULE:FREQ=YEARLY;UNTIL=19521026T020000Z;BYMONTH=10;BYMONTHDAY=21,22,23,2
 4,25,26,27;BYDAY=SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19531004T030000
RRULE:FREQ=YEARLY;UNTIL=19601002T020000Z;BYMONTH=10;BYMONTHDAY=2,3,4,5,6,
 7,8;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19550417T020000
RRULE:FREQ=YEARLY;UNTIL=19560422T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19580420T020000
RRULE:FREQ=YEARLY;UNTIL=19590419T020000Z;BYMONTH=4;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19610326T020000
RRULE:FREQ=YEARLY;UNTIL=19630331T020000Z;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19611029T030000
RRULE:FREQ=YEARLY;UNTIL=19671029T020000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19640322T020000
RRULE:FREQ=YEARLY;UNTIL=19670319T020000Z;BYMONTH=3;BYMONTHDAY=19,20,21,22
 ,23,24,25;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:BST
TZOFFSETFROM:+0100
TZOFFSETTO:+0100
DTSTART:19681026T230000
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19720319T020000
RRULE:FREQ=YEARLY;UNTIL=19800316T020000Z;BYMONTH=3;BYMONTHDAY=16,17,18,19
 ,20,21,22;BYDAY=SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19721029T030000
RRULE:FREQ=YEARLY;UNTIL=19801026T020000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:DAYLIGHT
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:19810329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19811025T020000
RRULE:FREQ=YEARLY;UNTIL=19891029T010000Z;BYMONTH=10;BYMONTHDAY=23,24,25,2
 6,27,28,29;BYDAY=SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19901028T020000
RRULE:FREQ=YEARLY;UNTIL=19951022T010000Z;BYMONTH=10;BYDAY=4SU
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0000
TZOFFSETTO:+0000
DTSTART:19960101T000000
END:STANDARD
BEGIN:STANDARD
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
DTSTART:19961027T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260503T154654Z
DTSTART;VALUE=DATE-TIME:20251117T140000
DTEND;VALUE=DATE-TIME:20251117T150000
SUMMARY:Cellular Interfaces Seminar: Mechano-sensing through self assembl
 y at the cell membrane: the example of caveolae
TZID:Europe/London
UID:20251117-8ac672c59a4d087d019a501059e22573@warwick.ac.uk
CREATED:20251112T121736Z
DESCRIPTION:Mechano-sensing through self assembly at the cell membrane: t
 he example of caveolae Professor Pierre Sens\, Institute Curie Abstract:
  Mechano-sensing at the cell membrane often involves change of conformat
 ion of proteins under stress\, such as the opening of mechanically-gated
  channels or the unfolding adhesion proteins. Another class of mechano-s
 ensing systems relies the assembly and disassembly of multi-protein comp
 lexes. In this talk\, I will discuss the case of caveoale\, small invagi
 nated nanodomains at the plasma membrane of many cell types\, that have 
 been classically involved in membrane trafficking and signalling. After 
 presenting experimental evidence - obtained by collaborators - of the ro
 le of caveolae mechanics in the control of different signalling pathway\
 , I will describe a thermodynamic model of caveolae stability under tens
 ion based on the phase separation of membrane-associated proteins into i
 nvaginated\, multi-component membrane domains. I will in particular disc
 uss the importance of the multi-component nature of caveolae\, enriched 
 in the curvature-generating membrane protein caveolin\, and stabilised b
 y the curvature-dependent binding of cytosolic proteins\, including cavi
 n which can form a rigid coat over the caveolin domains\, and the ATPase
  EHD2 which can form ring-like oligomers at the caveolae neck. If time p
 ermits\, I will discuss the consequence of caveolae mechano-signalling o
 n cell polarity and directional migration. Biography: Pierre Sens is res
 earch director at CNRS and group leader at Institut Curie\, in Paris. Pi
 erre received his PhD from the University of Strasbourg (France) in the 
 field of soft condensed matter and complex fluids. He then moved to U.C.
  Santa Barbara for a couple of years\, then to Institut Weizmann in Isra
 el for a year\, before coming back to France with the CNRS. Pierre is a 
 theoretical physicist applying physical concepts to the study of biologi
 cal systems\, in particular to living cells. He investigates the active 
 mechanics of cells\, with a focus on cell motility and mechano-sensation
 . Pierre also work on the physical basis of cellular homeostasis such as
  cell volume and density regulation. Pierre also studies the physical pr
 inciples of intracellular organisation\, in particular the generation an
 d maintenance of cellular organelles\, and the physics of cellular membr
 anes\, particularly membrane shaping by proteins and the cytoskeleton.
LOCATION:A151 (MBU)\, Medical School Building \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Cellular Interfaces Seminar
LAST-MODIFIED:20251112T121736Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
END:VCALENDAR