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BEGIN:VEVENT
DTSTAMP:20260503T234334Z
DTSTART;VALUE=DATE-TIME:20251007T140000
DTEND;VALUE=DATE-TIME:20251007T150000
SUMMARY:BMS Extra Seminar: Distinctive regulation of RNA polymerase II tr
 anscription in quiescence\, Dr Pei-Yun Jenny Wu\, Institute of Biochemis
 try and Cellular Genetics
TZID:Europe/London
UID:20251007-8ac672c59956aa73019957e648b71185@warwick.ac.uk
CREATED:20250917T134339Z
DESCRIPTION:Abstract: The alternation between proliferation and quiescenc
 e plays integral roles in cellular adaptation and in diverse aspects of 
 organismal function. In multicellular eukaryotes\, quiescence is essenti
 al for development\, stem cell homeostasis\, and tissue repair. In addit
 ion\, many unicellular organisms remain quiescent for extended durations
  in order to survive in challenging environments. Surprisingly\, despite
  the importance and prevalence of this critical state\, we are only begi
 nning to understand how cells sustain quiescence and retain the capacity
  to resume growth. Although quiescence was previously considered to be a
  passive condition during which cells are simply non-proliferating\, it 
 has now become clear that it is an actively-controlled physiological sta
 te. Quiescent cells in different organisms contain reduced overall RNA l
 evels\, and their re-entry in the division cycle is associated with sign
 ificant changes in gene expression. These common features suggest that s
 pecific mechanisms of transcriptional control may be crucial for the alt
 ernation between quiescence and proliferation. We therefore set out to a
 ddress this question\, using nitrogen starvation in the fission yeast S.
  pombe as a model. Our results reveal that compared to proliferating cel
 ls\, quiescent cells show dramatic differences in their profiles of RNA 
 polymerase II (Pol II) binding along transcription units. This is accomp
 anied by changes in the modification patterns of the Pol II carboxy-term
 inal domain (CTD)\, pointing to an altered control of the Pol II transcr
 iption cycle. Notably\, analyses of nascent transcription through mappin
 g Pol II active sites and metabolic labeling uncovered a striking altera
 tion in transcription termination at coding regions across the genome\, 
 regardless of their level of expression. Furthermore\, conditional inact
 ivation of termination factors gave rise to cellular phenotypes that ind
 icate critical quiescence-specific functions. Our study thus provides ev
 idence for a distinctive modulation of RNA polymerase II activity in qui
 escence that may be a crucial contributor to the maintenance of a quiesc
 ent state and for cell cycle re-entry. Biography: Pei-Yun Jenny Wu recei
 ved her doctoral training in the laboratory of Dr Fred Winston at Harvar
 d Medical School\, investigating the structure and function of the SAGA 
 chromatin modifying complex. She then pursued her postdoctoral work with
  Dr. Paul Nurse at Rockefeller University\, focusing on the mechanisms t
 hat control DNA replication. In 2012\, she established her research labo
 ratory in France\, first at the Institute of Genetics and Development of
  Rennes\, followed by a move to the Institute of Biochemistry and Cellul
 ar Genetics in Bordeaux in 2022. Her laboratory uses the fission yeast S
 chizosaccharomyces pombe to explore the processes that regulate DNA repl
 ication and genome maintenance\, as well as the interplay between genome
  organization\, gene expression and cellular physiology.
LOCATION:MTC Lecture Theatre \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20250917T134339Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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