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BEGIN:VEVENT
DTSTAMP:20260502T151307Z
DTSTART;VALUE=DATE-TIME:20260605T131500
DTEND;VALUE=DATE-TIME:20260605T141500
SUMMARY:BMS Seminar: Collective state transitions in epithelial dynamics 
 through mechanochemical feedback\, Dr Tsuyoshi Hirashima\, Mechanobiolog
 y Institute/Department of Physiology\, National University of Singapore
TZID:Europe/London
UID:20260605-8ac672c49d3cb3aa019d4d41606f64d7@warwick.ac.uk
CREATED:20260402T082206Z
DESCRIPTION:Abstract: Collective cell motion is a fundamental phenomenon 
 at the interface of cell biology\, developmental biology\, and non-equil
 ibrium physics. However\, how mechanical and chemical cues are integrate
 d at the cellular level to generate coordinated multicellular behaviours
  remains incompletely understood. In this talk\, I will present a mechan
 o-signalling feedback mechanism that couples ERK activity with mechanica
 l force generation and cell movement\, giving rise to robust spatiotempo
 ral coordination observed both in vitro and in vivo. I will first review
  prior work establishing ERK-mediated feedback as a prototypical example
  of an active epithelial system\, in which biochemical signalling and me
 chanics are dynamically intertwined. Building on this framework\, I will
  then introduce our recent findings that reveal two distinct but coupled
  types of transitions governing collective dynamics: a rigidity transiti
 on\, which modulates the mechanical state of the tissue\, and a percolat
 ion transition\, which controls the connectivity required for long-range
  signal propagation. I will discuss how the interplay between these tran
 sitions defines the dynamical regimes of epithelial tissues and enables 
 the emergence of coordinated patterns of activity. Biography: Tsuyoshi H
 irashima was trained as a mathematical biologist and received his Ph.D. 
 from Kyushu University in 2011. During his Ph.D. training\, he studied m
 athematical modeling on tissue morphogenesis in development under the me
 ntorship of Prof. Yoh Iwasa. He moved to Kyoto University as a JSPS post
 doc research fellow and learned experimental skills in cell and developm
 ental biology at Prof. Ryoichiro Kageyama’s lab. He then joined the facu
 lty of Kyoto University as an Assistant Professor in 2014\, a senior lec
 turer in 2017\, and an Associate Professor at the Hakubi Center for Adva
 nced Research in 2021. He has since joined MBI in 2022 to further pursue
  his scientific and personal curiosity. He has been on the editorial boa
 rd of Journal of Theoretical Biology since 2022.
LOCATION:MTC Lecture Theatre \, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260402T082206Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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