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BEGIN:VEVENT
DTSTAMP:20260505T025743Z
DTSTART;VALUE=DATE-TIME:20230706T153000
DTEND;VALUE=DATE-TIME:20230706T173000
SUMMARY:Dual Major InReach10x Seminar - Nick Dale
TZID:Europe/London
UID:20230706-8a1785d88895e8e00188be5b98d07b05@warwick.ac.uk
CREATED:20230621T105234Z
DESCRIPTION:Talk by Nick Dale “CO2 -not just a waste product” CO2 is comm
 only regarded as the inevitable by-product of cellular metabolism. The t
 hesis of my talk is that although CO2 is a waste product\, it also conve
 ys in functional information in physiological systems. I will give an ac
 count of our discovery that ion channels called connexins are directly s
 ensitive to CO2. I will discuss the mechanism of CO2 binding and channel
  opening and show high resolution cryoEM structure. I will show that one
  of these CO2-sensitive connexins is important in the regulation of brea
 thing. I will discuss our latest results showing that there are many mor
 e connexins that are directly sensitive to CO2 than we first thought. CO
 2 sensitive connexins are present in all the major organs of the body su
 ggesting that CO2 acts to signal information in many diverse contexts\, 
 and I will discuss an exciting emerging role for CO2-mediated signalling
  in the maintenance of myelin. I will finish with our investigations of 
 the receptors that insects use to sense CO2 and our efforts to create no
 vel tools from these receptors to measure CO2 production in real time in
  physiological systems.
LOCATION:Helen Martin Studio
CATEGORIES:IAS Event,Accolade
LAST-MODIFIED:20230621T105234Z
ORGANIZER;CN=Katie Reynolds:
END:VEVENT
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