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BEGIN:VEVENT
DTSTAMP:20260508T013315Z
DTSTART;VALUE=DATE-TIME:20230117T120000
DTEND;VALUE=DATE-TIME:20230117T130000
SUMMARY:SLS/WMS Microbiology and Infectious Diseases seminar: Leishmania 
 parasite sequestration in the sand fly vector\, Dr Jack Sunter
TZID:Europe/London
UID:20230117-8a1785d8859679cd01859b87a80f1ebf@warwick.ac.uk
CREATED:20230110T115356Z
DESCRIPTION:Abstract: Leishmania spp. are flagellated eukaryotic parasite
 s that cause leishmaniasis\, a neglected tropical disease with a range o
 f different pathologies. Leishmania has a complex life cycle with multip
 le developmental forms as it cycles between a sand fly vector and a mamm
 alian host. Within the sand fly\, Leishmania parasites have two major mo
 rphological forms\, a motile promastigote and a haptomonad\, which is at
 tached to the stomodeal valve through a shortened and modified flagellum
 . Dissecting haptomonad development and attachment is critical to unders
 tanding parasite transmission\; however\, studies of haptomonads are lim
 ited\, as this is a technically challenging life cycle form to investiga
 te. To gain an in-depth understanding of the in vivo haptomonad cellular
  architecture and organisation\, we combined two volume electron microsc
 opy techniques – serial block face-scanning electron microscopy (SBF-SEM
 ) and serial electron microscopy tomography – generating high resolution
  3D models of haptomonads attached to the stomodeal valve. Haptomonads w
 ere densely packed around the valve and were attached through the tip of
  a shortened flagellum. The attachment interface was filled\, on the fla
 gellum side\, with an electron-dense plaque that connected to abundant f
 ilaments and filament bundles. Next\, we generated attached L. mexicana 
 haptomonads in vitro and confirmed that the fine ultrastructure of these
  forms was comparable to that of haptomonads found in vivo. Using compar
 ative proteomic approaches\, we identified proteins locating to the atta
 chment interface and a number of these proteins are present in other kin
 etoplastid parasites. Deletion analysis using CRISPR/Cas9 compromised Le
 ishmania attachment both in vitro and in the sand fly\, confirming that 
 we have identified critical components of the attachment interface. This
  provides the first molecular insights into a kinetoplastid parasite vec
 tor attachment interface\, which will underpin our understanding of this
  crucial interaction. Biography: I am a molecular cell biologist and mic
 roscopist by training who is fascinated by the ability of parasites to s
 ubvert their host organism enabling them to thrive. I studied Biochemist
 ry at the University of Cambridge\, before spending nearly a year workin
 g at the International Livestock Research Institute in Nairobi. I then r
 eturned to Cambridge where I did my PhD supervised by Professor Mark Car
 rington studying the cell biology of the parasite Trypanosoma brucei. I 
 then switched to the University of Oxford for my post-doc with Professor
  Keith Gull. In 2017\, I took the opportunity to come to Oxford Brookes 
 University to establish my own research group. In my lab\, we use the fl
 agellated eukaryotic parasites Trypanosoma brucei and Leishmania mexican
 a to understand the fundamental processes that define the cell organisat
 ion underlying parasite interactions with their hosts and vectors. The d
 istinctive shape of trypanosomes and Leishmania is formed by a corset of
  cross-linked microtubules that are just beneath the cell membrane and b
 oth have a flagellum that provides the propulsive force enabling them to
  move. We focus on understanding the morphogenesis of cytoskeletal-membr
 ane interfaces that contribute to i) cell and substrate attachments\, ii
 ) interaction with the insect vector and mammalian host.
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Microbiology and
  Infectious Disease seminar
LAST-MODIFIED:20230110T115356Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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