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BEGIN:VEVENT
DTSTAMP:20260508T023428Z
DTSTART;VALUE=DATE-TIME:20221213T120000
DTEND;VALUE=DATE-TIME:20221213T131000
SUMMARY:SLS/WMS Microbiology and Infectious Disease seminar: Optical modu
 lation of bacterial membrane potential\, Tailise de Souza Guerreiro Rodr
 igues\, School of Life Sciences
TZID:Europe/London
UID:20221213-8a1785d884a43d060184a8e972df0fb5@warwick.ac.uk
CREATED:20221209T133445Z
DESCRIPTION:Abstract:The bacterial membrane potential is dynamic and play
 s important signalling roles. Yet\, little is still known about the mech
 anisms of bacterial membrane potential dynamics regulation –owing in par
 t to lack of appropriate research tools. Optical modulation of bacterial
  membrane potential could fill this gap and provide a new approach to st
 udying and controlling bacterial physiology and electrical signalling. H
 ere\, we show that a membrane-targeted azobenzene (Ziapin2) can be used 
 to photo-modulate the membrane potential in cells of the Gram-positive b
 acterium Bacillus subtilis. We found that upon exposure to blue-green li
 ght\, isomerisation of Ziapin2 in the bacteria membrane induces hyperpol
 arisation. To investigate the origin of this phenomenon\, we examined io
 n-channel-deletion strains and ion channel blockers. We found that in pr
 esence of a chloride channel blocker\, or in absence of a potassium tran
 sporter\, the hyperpolarisation response is attenuated. These results re
 veal that the Ziapin2 isomerisation can induce ion channel opening in th
 e bacterial membrane and suggest that Ziapin2 can be used for studying a
 nd controlling bacterial electrical signalling. This new optical tool ca
 n contribute to better understand various microbial phenomena\, such as 
 biofilm electric signalling and antimicrobial resistance. Biography: Tai
 lise Souza did her PhD in cell biology and is now a Postdoc in Asally’s 
 laboratory\, at School of Life Sciences\, University of ÌÇÐÄTV. Her cur
 rent work focus on bioelectricity of microorganisms like the Gram-positi
 ve bacteria Bacillus subtilis and the budding yeast Saccharomyces cerevi
 siae. Bioelectricity is an area of research now listed as a spotlight to
 pic by BBSRC and her work in Asally lab aims to connect it to applicatio
 ns ranging from optical modulation of membrane potential to developing d
 iagnostic tools for proliferative microorganisms. A member of the Policy
  Advisory Panel of the Biochemical Society\, Tailise has also been engag
 ing in increasing awareness of the threat that antimicrobial resistance 
 poses to our society.
LOCATION:BSR1\, School of Life Sciences
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Microbiology and
  Infectious Disease seminar
LAST-MODIFIED:20221209T133445Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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