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BEGIN:VEVENT
DTSTAMP:20260510T193138Z
DTSTART;VALUE=DATE-TIME:20221109T130000
DTEND;VALUE=DATE-TIME:20221109T140000
SUMMARY:BMS Seminar: Sodium in the Dermis Co-locates to Glycosaminoglycan
  Scaffold\, with Diminishment in Type 2 Diabetes Mellitus\, Dr Thomas Ba
 rber\, Division of Biomedical Sciences\, WMS
TZID:Europe/London
UID:20221109-8a1785d88317904a0183376493c83346@warwick.ac.uk
CREATED:20221027T105403Z
DESCRIPTION:Abstract: Background: Dietary sodium intake mismatches urinar
 y sodium excretion over prolonged periods. Our aims were to localize and
  quantify electrostatically bound sodium within human skin using triple 
 quantum filtered (TQF) protocols for magnetic resonance imaging (MRI) an
 d spectroscopy (MRS)\, and explore dermal sodium in Type 2 Diabetes Mell
 itus (T2D). Methods: We recruited adult participants with T2D (n=9) and 
 euglycemic participants with no history of Diabetes Mellitus (n=8). All 
 had undergone lower limb amputations or abdominal skin reduction surgery
  for clinical purposes. We used 20mm in-plane resolution 1H MRI to visua
 lise anatomical skin regions ex vivo from skin biopsies taken intra-oper
 atively\, 23Na TQF MRI/MRS to explore distribution and quantification of
  freely dissolved and bound sodium and Inductively Coupled Plasma Mass S
 pectrometry to quantify sodium in selected skin samples. Results: Human 
 dermis has a preponderance (>90%) of bound sodium that co-localizes with
  the glycosaminoglycan (GAG) scaffold. Bound and free sodium have simila
 r anatomical locations. T2D associates with a severely reduced dermal bo
 und sodium capacity. Conclusion: We provide the first evidence for high 
 levels of bound sodium within human dermis\, co-locating to the GAG scaf
 fold\, consistent with a dermal ‘third space repository’ for sodium. T2D
  associates with diminished dermal electrostatic binding capacity for so
 dium. Biography: Dr Barber has been employed as an Associate Professor a
 nd Honorary Consultant Endocrinologist at University of ÌÇÐÄTV and Univ
 ersity Hospitals Coventry and ÌÇÐÄTVshire (UHCW) since 2010. Dr. Barber
  has published >120 papers in leading peer-reviewed journals (H-index 34
 \; i10-index 64)\, including a recent paper in Lancet Diabetes and Endoc
 rinology on ethnic-specific cut-points for obesity. Dr. Barber presents 
 regularly as an invited speaker at scientific meetings both nationally a
 nd internationally. He engages regularly with national media on topics r
 elating to human metabolism and Obesity. As scientific lead for the Huma
 n Metabolism Research Unit\, his current research interests include the 
 impact of human metabolism on the development of Obesity\, and novel str
 ategies to prevent and manage Obesity and Diabetes Mellitus within the p
 opulace. As Clinical Lead for the Obesity service at UHCW\, Dr. Barber c
 ombines clinical duties with clinical and translational research.
LOCATION:via MS Teams Only (please contact j.k.bains@warwick.ac.uk for de
 tails)
CATEGORIES:BiomedicalSciences,DivisionalSeminars,HealthGRP
LAST-MODIFIED:20221027T105403Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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