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BEGIN:VEVENT
DTSTAMP:20260509T182035Z
DTSTART;VALUE=DATE-TIME:20211110T130000
DTEND;VALUE=DATE-TIME:20211110T140000
SUMMARY:BMS Seminar: Streptococcus pneumoniae colonisation of the human n
 asopharynx\, Dr Caroline Weight\, Senior Research Fellow\, Division of I
 nfection and Immunity\, University College London
TZID:Europe/London
UID:20211110-8a1785d87c555391017c766c6aee7316@warwick.ac.uk
CREATED:20211013T151411Z
DESCRIPTION:Abstract: Streptococcus pneumoniae is a common coloniser of t
 he upper respiratory tract\, but infections and inflammation occurs afte
 r dissemination into the lungs causing pneumonia\, and invasive pneumoco
 ccal disease occurs following dissemination into the bloodstream causing
  septicaemia and across the blood brain barrier causing meningitis. The 
 pneumococcus claims over 800\,000 lives per year\, primarily in the unde
 r 5 yrs and over 65 yrs\, with the highest burden in Africa and South Ea
 st Asia. Control of carriage is clearly an important factor in preventin
 g advancement to invasive disease and transmission. There are over 100 s
 erotypes and although the pneumococcal vaccines have been very successfu
 l in decreasing invasive disease\, they have had little effect on carria
 ge\, particularly because of serotype replacement of the non-vaccine ser
 otypes. Bacterial association with the nasal epithelium and epithelial-d
 erived innate immunity is likely to be important for the outcome of pneu
 mococcal colonisation. Using a combination of in vivo datasets\, in vitr
 o cell assays and the unique Experimental Human Pneumococcal Challenge m
 odel\, we have been investigating pneumococcal-epithelial interactions i
 n order to understand the cellular and molecular dynamics during infecti
 on. Biography: Caroline received her PhD from the Institute of Food Rese
 arch and the University of East Anglia working on the infection mechanis
 ms of Toxoplasma gondii in the small intestine. She undertook her first 
 postdoctoral position at Emory University\, Atlanta USA investigating ti
 ght junction protein signalling in the context of Inflammatory Bowel Dis
 ease. Following on\, she translated her signalling work experience to T 
 cell biology at Lund University in Sweden. Now Caroline works at UCL in 
 Rob Heydermans group as a senior research fellow\, focussing on the colo
 nisation of Streptococcus pneumoniae by the human nasopharyngeal epithel
 ium. She is lead principal investigator on a number of project grants wh
 ich are aimed at advancing the complexity of the systems she uses to inv
 estigate host-pathogen interactions.
LOCATION:via MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20211013T151411Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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