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BEGIN:VEVENT
DTSTAMP:20260512T151609Z
DTSTART;VALUE=DATE-TIME:20200513T130000
DTEND;VALUE=DATE-TIME:20200513T140000
SUMMARY:Virtual BMS Divisional Seminar: Cellular and molecular mechanisms
  of primary microcephaly\, Dr Patricia Garcez\, Visiting Academic Resear
 cher\, Sir Dunn School of Pathology\, University of Oxford
TZID:Europe/London
UID:20200513-8a1785d871405ebe01719cc7cb5b6693@warwick.ac.uk
CREATED:20200423T085814Z
DESCRIPTION:Abstract: Primary microcephaly is a severe brain malformation
  that leads to a lifelong range of impairments such as intellectual disa
 bility\, motor\, hearing and visual malfunctions. Microcephaly aetiologi
 es vary from genetic abnormalities to external factors such as the STORC
 H infections (Syphilis\, Toxoplasma\, Rubella\, Cytomegalovirus and Herp
 es virus). Recently\, Zika virus (ZIKV) has been associated with microce
 phaly and other brain abnormalities\; however\, the molecular consequenc
 es of ZIKV to human brain development are still not fully understood. Th
 is talk aims to discuss the alterations in human brain organoids and neu
 rospheres derived from induced pluripotent stem cells infected with ZIKV
 . Combining proteomics and mRNA transcriptional profiling\, over 500 pro
 teins and genes associated with ZIKV infection were found to be differen
 tially expressed. These genes and proteins provide an interactome map\, 
 which indicates that ZIKV controls the expression of RNA processing bodi
 es\, miRNA biogenesis and splicing factors required for self-replication
 . It also suggests that impairments in the molecular pathways underpinni
 ng cell cycle and neuronal differentiation are caused by ZIKV. These res
 ults point to biological mechanisms implicated in brain malformations\, 
 which are important to further the understanding of ZIKV infection and c
 an be exploited as therapeutic potential targets to mitigate it. Please 
 contact j.k.bains@warwick.ac.uk for zoom link and password. Staff/studen
 ts: Zoom details to be found here: /fac/sci/med/sta
 ffintranet/divisions/bms/virtual_community
LOCATION:via Zoom
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20200423T085814Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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