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BEGIN:VEVENT
DTSTAMP:20260513T003454Z
DTSTART;VALUE=DATE-TIME:20200116T123000
DTEND;VALUE=DATE-TIME:20200116T133000
SUMMARY:BMS seminar at CSRL: Advanced Glycation End Products: a new playe
 r in obesity related infertility\, Jennifer Hutchinson\, Hudson Institut
 e of Medical Research\, Australia
TZID:Europe/London
UID:20200116-8a1785d86f1db170016f7f96817763a5@warwick.ac.uk
CREATED:20200107T103927Z
DESCRIPTION:Abstract: Obesity is a global pandemic: In England\, 64% of t
 he population is overweight or obese\, critically ~30% of women of repro
 ductive age are obese (NHS Digital). Obesity reduces both natural and IV
 F pregnancy success\, and increases miscarriage & preeclampsia risk. ‘To
 xic’ Advanced Glycation End-Products (AGEs)\, formed when reducing sugar
 s react with the free amino group on proteins\, a spontaneous process wh
 ich happens endogenously within the body\, and also during food preparat
 ion. AGEs are four-fold elevated in the uterine cavity of obese\, infert
 ile women versus lean. AGEs equimolar to the obese uterine cavity negati
 vely impact the development of the preimplantation embryo. When exposed 
 to elevated AGEs\, fewer blastocysts hatch from the zona pellucida\, a c
 ritical step to allow embryo adhesion and implantation to the maternal e
 ndometrium. By day five of development\, these embryos also have fewer t
 rophectoderm cells- critical for adhesion\, implantation\, and ultimatel
 y placentation- and exhibit reduced implantation competence. Furthermore
 \, the maternal endometrium is significantly affected by elevated AGEs\,
  with all cell types showing compromised functions. Obesity related AGEs
  provide a critical link between obesity and reduced fertility\, and pre
 conception reduction of these AGEs may improve fertility outcomes for th
 ese women.
LOCATION:CSRL Seminar Room\, CSB\, UHCW
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20200107T103927Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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