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BEGIN:VEVENT
DTSTAMP:20260513T120410Z
DTSTART;VALUE=DATE-TIME:20191205T123000
DTEND;VALUE=DATE-TIME:20191205T133000
SUMMARY:BMS Seminar: Lessons from in utero stress related to epigenetic a
 lterations\, Professor George Mastorakos\, Department of Endocrinology\,
  University of Athens
TZID:Europe/London
UID:20191205-8a1785d86e93ba8f016eb2bdae7728e0@warwick.ac.uk
CREATED:20191129T084245Z
DESCRIPTION:Abstract: Stress is one of the commonest and underappreciated
  causes of reproductive frailty in women. The stress system leads to ada
 ptive responses via mobilization of hormonal systems. Adaptability and r
 esistance to stress are fundamental to life. The response to stressors d
 epends on the type of stressor\, the timing and duration of stress\, the
  genetic predisposition\, personality characteristics\, and the way of c
 oping with stress. In pregnancy\, maternal stress is known to disturb fe
 tal glucocorticoid environment. In utero stress exposure is a significan
 t predictor of subsequent adult telomere length. In humans\, maternal ex
 posure to prenatal psychosocial stress could be associated with decrease
 d insulin sensitivity in the offspring assessed during young adulthood a
 s well as in animals in intrauterine growth restriction (IUGR) cases. So
 me of the metabolic consequences of IUGR can be mitigated by ensuring ea
 rly appropriate catchup growth\, while avoiding excessive weight gain if
  relative hypercortisolism is not installed. The effect of maternal stre
 ss on fetuses regarding fetal HPA axis responsiveness (increased or decr
 eased) remains under investigation. Animal studies confirmed that increa
 se in stress hormones and pro-inflammatory cytokines in the fetal compar
 tment during sensitive or critical developmental windows can impact the 
 structure and function of the brain and peripheral targets which are rel
 ated to body composition\, energy balance homeostasis\, and metabolic fu
 nction (i.e. adipose tissue\, pancreas\, and liver). Maternal stress and
  depression are associated with structural and functional changes of bra
 in parts such as hippocampus. In utero stress modifies epigenetically co
 mponents of the HPA axis which can be transmitted transgenerationally. E
 pigenetic changes result in altered gene expression\, ultimately affecti
 ng the risk for mental disorders.
LOCATION:CSRL Seminar Room\, CSB\, UHCW
CATEGORIES:BiomedicalSciences,BMS_TEM,CSRL
LAST-MODIFIED:20191129T084245Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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