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BEGIN:VEVENT
DTSTAMP:20260513T234537Z
DTSTART;VALUE=DATE-TIME:20190716T120000
DTEND;VALUE=DATE-TIME:20190716T130000
SUMMARY:WMS/SLS Micro Seminar: The evolutionary history of tuberculosis: 
 Insights from ancient DNA\, Dr Anne C. Stone\, School of Archaeology at 
 PalaeoBarn\, University of Oxford
TZID:Europe/London
UID:20190716-8a1785d86b2d9fa4016b4609c1bd1e36@warwick.ac.uk
CREATED:20190712T102849Z
DESCRIPTION:Abstract: Tuberculosis (TB) has long been a scourge of humans
 \, as well as other animals. Here\, I will discuss how ancient DNA allow
 s us to examine the history of Mycobacterium tuberculosis and related st
 rains in the M. tuberculosis complex (MTBC) which cause the disease. In 
 particular\, I will focus on patterns of pathogen exchange before and af
 ter the ā€œAge of Exploration/Colonizationā€ and discuss ways that TB may h
 ave adapted to humans and other animals. We previously analyzed MTBC gen
 omes from three 1000-year old skeletal TB cases from coastal Peru and fo
 und that they are closely related to strains in sea mammals (specificall
 y Southern Hemisphere pinnipeds). However\, it is unclear whether these 
 pinniped-derived MTBC strains spread to inland parts of South America as
  well as North America by human-to-human transmission or whether differe
 nt strains spread into the Americas via another route. After contact\, E
 uropean TB strains were introduced\, apparently replacing pre-contact st
 rains but the timing and extent of this is unknown. New analyses show ev
 idence for the spread of pinniped-derived MTBC strains to people in non-
 coastal areas\, likely due to human-to-human transmission. Our data also
  suggest that modern American strain distributions reflect the introduct
 ion of strains commonly circulating in the source areas of colonists. Sh
 ort Bio: Anne Stone is Regentsā€™ Professor in the School of Human Evoluti
 on and Social Change at the Arizona State University. Currently\, her re
 search focuses on population history and understanding how humans and th
 e great apes other primates have adapted to their environments\, includi
 ng their disease and dietary environments. This includes: (a) Native Ame
 rican population history\, (b) the evolutionary history of the Great Ape
 s\, and (c) understanding the evolutionary history of mycobacteria (spec
 ifically the causative agents of tuberculosis and leprosy). Stone has be
 en a Fulbright Fellow (1992-93)\, a NIH NRSA postdoctoral fellow (1997-1
 998)\, and a Kavli Scholar (2007). She is a fellow of the American Assoc
 iation for the Advancement of Science (2011) and a member of the Nationa
 l Academy of Sciences (2016). Stone currently serves as a senior editor 
 of Molecular Biology and Evolution.
LOCATION:MBU (A151)\, Medical School Building
CATEGORIES:BiomedicalSciences,BMS_MI,Joint WMS/SLS Micro
LAST-MODIFIED:20190712T102849Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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