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BEGIN:VEVENT
DTSTAMP:20260610T220300Z
DTSTART;VALUE=DATE-TIME:20181212T130000
DTEND;VALUE=DATE-TIME:20181212T140000
SUMMARY:BMS Seminar: Successful repair of the spinal cord by Professor Ca
 therina Becker\, University of Edinburgh
TZID:Europe/London
UID:20181212-8a1785d8675a41e1016783b6ff1c74a9@warwick.ac.uk
CREATED:20181206T153931Z
DESCRIPTION:Abstract: Spinal cord injury leads to a massive response of i
 nnate immune cells (microglia\, macrophages\, neutrophils) both in non-r
 egenerating mammals and in successfully regenerating zebrafish\, but the
  role of these immune cells in functional spinal cord regeneration in ze
 brafish is unclear. We have recently established a spinal cord lesion pa
 radigm in 3-day-old larval zebrafish. These show axonal and neuronal rep
 air within 48 hours\, with axons actively navigating a complex extracell
 ular matrix. We use this highly accessible system to determine interacti
 ons of innate immune cells and signals in successful spinal cord repair.
  Inhibiting inflammation reduces and promoting it accelerates axonal reg
 eneration in larval zebrafish. Similarly\, regeneration of motor neurons
  is promoted by signals from the innate immune systems. Mutant analyses 
 show that peripheral macrophages\, but not neutrophils or microglia\, ar
 e necessary for axon regeneration. Macrophage-less irf8 mutants show pro
 longed inflammation with elevated levels of Il-1β and Tnf-α. Decreasing 
 Il-1β levels or number of Il-1β+ neutrophils rescues functional regenera
 tion in irf8 mutants. However\, during early regeneration\, interference
  with Il-1β function impairs regeneration in irf8 and wildtype animals. 
 Inhibiting Tnf-α does not rescue axonal growth in irf8 mutants\, but imp
 airs it in wildtype animals\, indicating a pro-regenerative role of Tnf-
 α Hence\, inflammation is tightly and dynamically controlled by macropha
 ges to promote functional spinal cord regeneration in zebrafish.
LOCATION:GLT3\, ÌÇÐÄTV Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20181206T153931Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
END:VCALENDAR