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BEGIN:VEVENT
DTSTAMP:20260506T221347Z
DTSTART;VALUE=DATE-TIME:20230912T143000
DTEND;VALUE=DATE-TIME:20230912T153000
SUMMARY:BMS Seminar: Insights into early placental development - endometr
 ial organoids as a tool for studying endometrial function and pregnancy 
 outcomes\, Dr Tereza Cindrova-Davies\, Queen Mary University of London
TZID:Europe/London
UID:20230912-8a1785d789fd705f018a170cf764469a@warwick.ac.uk
CREATED:20230825T132222Z
DESCRIPTION:Abstract: Early human placental and embryonic development occ
 urs in a physiologically low oxygen environment. A responsive endometriu
 m creates a microenvironment essential for implantation of the conceptus
  and placentation. Uterine glands are the source of histotrophic nutriti
 on for the conceptus before the definitive haemochorial placenta is esta
 blished. Dysregulated endometrial maturation is implicated as the cause 
 of many adverse pregnancy outcomes\, including recurrent implantation fa
 ilure\, miscarriage\, pre-eclampsia and intrauterine growth restriction.
  There have been many technological developments in recent years which h
 ave generated excellent models of the endometrial and placental function
 \, and my research is at the forefront of some of these advances. My pil
 ot data provide evidence of increased cellular stress in endometrial gla
 nds of patients who later suffered early pregnancy losses (EPL). Interes
 tingly\, gland organoids derived from these biopsies retain characterist
 ics of the original tissues\, exhibiting increased cellular stress and l
 ower proliferation rates\, compared to organoids derived from patients w
 ho went on to have a successful pregnancy. Endometrial cellular stress c
 an be reduced and organoid formation efficiency increased by treating EP
 L organoids with certain anti-diabetic or lipid-lowering drugs known to 
 reduce cellular stress. I further demonstrated that gland organoids can 
 be derived from menstrual flow. This technique has wide-ranging impact f
 or non-invasive investigation and personalised approaches to treatment o
 f common gynaecological conditions\, such as endometriosis\, and reprodu
 ctive disorders\, including failed implantation after IVF and recurrent 
 miscarriage. Biography: Tereza Cindrova-Davies received her MPhil and Ph
 D from the University of Cambridge. Tereza worked as a research fellow a
 t the University of Cambridge between 2003-2022\, and currently holds a 
 lectureship at the Queen Mary University of London. Tereza has been awar
 ded international prizes for her research\, including the Elsevier Scien
 ce New Investigator Award at the IFPA meeting in Glasgow in 2005\, and t
 he Gabor Than award for ‘outstanding contributions to the field of place
 ntology in all its aspects’\, at the IFPA meeting in Graz in 2008. Terez
 a’s research has embraced the role of oxidative stress in normal and pat
 hological pregnancies\, placental senescence and H2S in pregnancy pathol
 ogies. Early pregnancy is a key area of Tereza’s current research intere
 sts. Her recent research concentrates on investigating early placental d
 evelopment\, the role of the human yolk sac and histotrophic nutrition. 
 Tereza has been instrumental in developing human and mouse organoid cult
 ures\, and used these to investigate the function of the endometrial gla
 nds in early pregnancy. In addition\, she recently succeeded in deriving
  physiologically relevant endometrial organoid cultures non-invasively f
 rom menstrual flow. Her future research is directed to explore why the m
 ajority of human pregnancies fail\, either before implantation or as a r
 esult of early pregnancy loss.
LOCATION:GLT3\, Medical School Building
CATEGORIES:BiomedicalSciences,DivisionalSeminars,CSRL
LAST-MODIFIED:20230825T132222Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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