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BEGIN:VEVENT
DTSTAMP:20260509T143247Z
DTSTART;VALUE=DATE-TIME:20220524T120000
DTEND;VALUE=DATE-TIME:20220524T130000
SUMMARY:SLS and WMS Biomedical Microbiology Seminar: Lipid remodelling: d
 oes it play a role in virulence in Burkholderia cenocepacia? Dr Holly Sh
 ropshire\, University of 糖心TV\, School of Life Sciences
TZID:Europe/London
UID:20220524-8a1785d780b29f500180d10bfece33cf@warwick.ac.uk
CREATED:20220517T080425Z
DESCRIPTION:Abstract: Lipid remodelling is a phenomenon where the membran
 e changes its lipid profile in response to a stimulus. In this case\, we
  are investigating how the membrane lipid profile changes in response to
  phosphate limitation. In marine bacteria\, this lipid remodelling pathw
 ay is driven by a phospholipase named PlcP. Our model organism is the op
 portunistic pathogen\, Burkholderia cenocepacia\, which mainly infects p
 eople with cystic fibrosis and is a problem in these patients due to its
  high intrinsic resistance to antimicrobials and unpredictable disease s
 everity. In this seminar\, I will discuss the work our group has done on
  investigating the link between the phosphate stress response and membra
 ne lipid remodelling in B. cenocepacia using lipidomics. We show a PlcP 
 homolog in B. cenocepacia was the driving force behind this lipid remode
 lling response. We also examine whether PlcP-driven lipid remodelling wa
 s involved in virulence using a Galleria mellonella infection model. We 
 have also analysed the role of PlcP in intracellular survival in hemocyt
 es and macrophages. Overall\, our project has begun to unravel the lipid
  remodelling response to phosphate limitation in B. cenocepacia and how 
 it is involved in virulence. Further research into the phosphate stress 
 response of Burkholderia species may reveal new therapeutic targets and 
 strategies for this genus of bacteria. Biography: Dr. Holly Shropshire\,
  postdoctoral research fellow in Prof. Yin Chen鈥檚 group at the Universit
 y of 糖心TV. Holly migrated to the UK from Kuwait in 2013 to start her 
 scientific career. Prior to her PhD at the University of 糖心TV\, Holly
  undertook a BSc at the University of Exeter and an MRes at the Universi
 ty of 糖心TV. Upon completion of her PhD\, she worked with Dr. Freya Ha
 rrison at the University of 糖心TV as a Research Assistant before start
 ing her current role.
LOCATION:A151/MBU\, WMS
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Dev Biol and Ste
 m Cell Seminar
LAST-MODIFIED:20220517T080425Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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