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BEGIN:VEVENT
DTSTAMP:20260510T032220Z
DTSTART;VALUE=DATE-TIME:20220428T120000
DTEND;VALUE=DATE-TIME:20220428T130000
SUMMARY:SLS/WMS Seminar: From Border to Crest: Deciphering dynamic gene r
 egulatory programmes driving neural crest lineages\, Ruth Williams\, Sto
 wers Institute for Medical Research // MRC WIMM University of Oxford
TZID:Europe/London
UID:20220428-8a1785d780466570018046af833201d2@warwick.ac.uk
CREATED:20220420T150419Z
DESCRIPTION:SLS/WMS Development Biology and Stem Cell Seminar Series Spon
 sored by Nikon and The Physiological Society Abstract: The neural crest 
 (NC) is a transient population of stem cell-like cells which generate nu
 merous derivatives in the vertebrate embryo. These include neurons and g
 lia of the peripheral and enteric nervous system and mesenchymal craniof
 acial elements including cartilage and bone\, and all skin pigments cell
 s. Neural crest progenitors are thought to originate from the neural pla
 te border territory which they share with cranial placode anlagen. Exact
 ly when and how cells within the neural plate border segregate into diff
 erent lineages remains elusive. Precise control of developmental process
 es is encoded in the genome in the form of gene regulatory networks (GRN
 s). Such multi-factorial systems are difficult to decode in vertebrates 
 owing to their complex gene hierarchies and dynamic molecular interactio
 ns. We recently reconstructed comprehensive GRNs governing early NC deve
 lopment in the chick embryo\, detailing transcriptional as well as epige
 nomic dynamics at population and single-cell levels. Using genome/epigen
 ome engineering in vivo\, we validated multiple regulatory layers govern
 ing NC ontogeny\, including NC-specific enhancers and novel trans-factor
 s. Furthermore\, identification and dissection of divergent upstream com
 binatorial regulatory codes has afforded new insights into opposing regu
 latory circuits that define neural and mesenchymal NC fates during early
  NC ontogeny. In addition\, we find shared regulatory programmes driving
  NC lineage progression from the neural plate border. Finally\, using si
 ngle-cell RNA-seq we find a subpopulation of early NC cells shares a tra
 nscriptional signature with neurula stage ectoderm cells and development
 al trajectory analysis shows neural plate border lineages only begin to 
 segregate at early neurulation.
LOCATION:IBRB Lecture Theatre
CATEGORIES:BiomedicalSciences,DivisionalSeminars,SLS/WMS Dev Biol and Ste
 m Cell Seminar
LAST-MODIFIED:20220420T150419Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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